851854-16-5Relevant academic research and scientific papers
The application of a monolithic triphenylphosphine reagent for conducting Ramirez gem-dibromoolefination reactions in flow
Roper, Kimberley A.,Berry, Malcolm B.,Ley, Steven V.
supporting information, p. 1781 - 1790 (2013/10/22)
The application of a monolithic form of triphenylphosphine to the Ramirez gem-dibromoolefination reaction using flow chemistry techniques is reported. A variety of gem-dibromides were synthesised in high purity and excellent yield following only removal of solvent and no further off-line purification. It is also possible to perform the Appel reaction using the same monolith and the relationship between the mechanisms of the two reactions is discussed.
Structure-activity relationships for the linker in a series of pyridinyl-alkynes that are antagonists of the metabotropic glutamate receptor 5 (mGluR5)
Bach, Peter,Nilsson, Karolina,Svensson, Tor,Bauer, Udo,Hammerland, Lance G.,Peterson, Alecia,Wallberg, Andreas,Oesterlund, Krister,Karis, David,Boije, Maria,Wensbo, David
, p. 4788 - 4791 (2007/10/03)
Studies of structure-activity relationships for the linker in a new series of metabotropic glutamate receptor 5 antagonists are presented together with in vitro and in vivo pharmacokinetic data.
