186692-68-2

Upstream product

• 6436-59-5 ethyl 2-methylthiazole-4-carboxylate 

Downstream Products

• 186692-69-3 Acetic acid (Z)-(1S,8S,9S,10R,11R)-9-(tert-butyl-dimethyl-silanyloxy)-13,13-dimethoxy-8,10,12,12-tetramethyl-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-11-triphenylsilanyloxy-tridec-3-enyl ester 
• 312730-84-0 (3S,6R,7S,8S,12Z,15S,16E)-phenyl 3,7-di-tert-butyldimethylsilyloxy-15-methoxycarbonyl-4,4,6,8,16-pentamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxo-12,16-heptadecadienoate 
• 297131-79-4 Acetic acid (Z)-(1S,8S,9S,10R,11R)-9-benzyloxy-11,13-bis-(tert-butyl-dimethyl-silanyloxy)-8,10,12,12-tetramethyl-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-tridec-3-enyl ester 
• 297131-91-0 Acetic acid (Z)-(1S,8S,9S,10R,11R)-9-benzyloxy-11-(tert-butyl-dimethyl-silanyloxy)-8,10,12,12-tetramethyl-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-13-oxo-tridec-3-enyl ester 
• 297131-82-9 (12Z,16E)-(3S,5R,6S,7S,8S,15S)-15-Acetoxy-7-benzyloxy-3,5-dihydroxy-4,4,6,8,16-pentamethyl-17-(2-methyl-thiazol-4-yl)-heptadeca-12,16-dienoic acid isopropyl ester 
• 297131-80-7 Acetic acid (Z)-(1S,8S,9S,10R,11R)-9-benzyloxy-11-(tert-butyl-dimethyl-silanyloxy)-13-hydroxy-8,10,12,12-tetramethyl-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-tridec-3-enyl ester 
• 297131-86-3 (Z)-(4S,7R,8S,9S,16S)-8-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-5,5,7,9-tetramethyl-16-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-oxacyclohexadec-13-ene-2,6-dione 
• 297131-85-2 (12Z,16E)-(3S,6R,7S,8S,15S)-7-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-15-hydroxy-4,4,6,8,16-pentamethyl-17-(2-methyl-thiazol-4-yl)-5-oxo-heptadeca-12,16-dienoic acid 
• 297131-83-0 (12Z,16E)-(3S,5R,6S,7S,8S,15S)-15-Acetoxy-7-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-4,4,6,8,16-pentamethyl-17-(2-methyl-thiazol-4-yl)-heptadeca-12,16-dienoic acid isopropyl ester 
• 297131-84-1 (12Z,16E)-(3S,6R,7S,8S,15S)-15-Acetoxy-7-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-4,4,6,8,16-pentamethyl-17-(2-methyl-thiazol-4-yl)-5-oxo-heptadeca-12,16-dienoic acid isopropyl ester 
• 297131-81-8 (12Z,16E)-(3S,5R,6R,7S,8S,15S)-15-Acetoxy-7-benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-4,4,6,8,16-pentamethyl-17-(2-methyl-thiazol-4-yl)-heptadeca-12,16-dienoic acid isopropyl ester 
• 188259-89-4 (Z)-(4R,6R,7R,8S,9S,16S)-8-(tert-Butyl-dimethyl-silanyloxy)-4-hydroxy-5,5,7,9-tetramethyl-16-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-6-triphenylsilanyloxy-oxacyclohexadec-13-en-2-one 
• 197233-32-2 (Z)-(6R,7R,8S,9S,16S)-8-(tert-Butyl-dimethyl-silanyloxy)-5,5,7,9-tetramethyl-16-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-6-triphenylsilanyloxy-oxacyclohexadec-13-ene-2,4-dione 
• 186692-71-7 (Z)-(4S,6R,7R,8S,9S,16S)-8-(tert-Butyl-dimethyl-silanyloxy)-4-hydroxy-5,5,7,9-tetramethyl-16-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-6-triphenylsilanyloxy-oxacyclohexadec-13-en-2-one 

Relevant academic research and scientific papers

Enantioselective total synthesis of epothilone A using multifunctional asymmetric catalyses

A catalytic version has now been developed for the enantioselective total synthesis of epothilone A (1). The key is the use of multifunctional asymmetric catalySes for a direct aldol reaction and cyanosilylation. This successful approach demonstrated the usefulness of these reactions for the catalytic asymmetric synthesis of complex molecules.