297131-79-4

Upstream product

• 186692-68-2 (1E,3S,5Z)-2-methyl-6-iodo-1-(2-methyl-1,3-thiazol-4-yl)-1,5-hexadien-3-yl acetate 
• 297131-72-7 {(1S,2S)-1-[(1R,2R)-2,4-Bis-(tert-butyl-dimethyl-silanyloxy)-1,3,3-trimethyl-butyl]-2-methyl-pent-4-enyloxymethyl}-benzene 
• 14642-79-6 benzyloxy-trimethylsilane 
• 297131-88-5 5-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-diphenyl-silanyloxy)-2,2,4-trimethyl-hexanoic acid ethyl ester 
• 297131-74-9 (3R,4S,5R)-5-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-3-hydroxy-2,2,4-trimethyl-hexanoic acid ethyl ester 
• 297131-77-2 (3R,4R,5S,6S)-5-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-2,2,4,6-tetramethyl-octanedioic acid diethyl ester 
• 297131-90-9 (3S,4S,5R,6R)-4-Benzyloxy-6,8-bis-(tert-butyl-dimethyl-silanyloxy)-3,5,7,7-tetramethyl-octanal 
• 297131-76-1 (E)-(4S,5R,6R)-4-Benzyloxy-6-(tert-butyl-dimethyl-silanyloxy)-5,7,7-trimethyl-oct-2-enedioic acid diethyl ester 
• 297131-73-8 (E)-(5S,6R)-6-Benzyloxy-7-(tert-butyl-diphenyl-silanyloxy)-5-methyl-hept-3-enoic acid methyl ester 
• 297131-75-0 (3R,4R,5R)-5-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-6-hydroxy-2,2,4-trimethyl-hexanoic acid ethyl ester 
• 297131-78-3 (3S,4S,5R,6R)-4-Benzyloxy-6-(tert-butyl-dimethyl-silanyloxy)-8-hydroxy-3,5,7,7-tetramethyl-octanal 
• 297131-89-6 (3R,4R,5R)-5-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-2,2,4-trimethyl-6-oxo-hexanoic acid ethyl ester 
• 297131-87-4 (2R,3R)-3-Benzyloxy-4-(tert-butyl-diphenyl-silanyloxy)-2-methyl-butyraldehyde 
• 220200-50-0 4-[(1E,5Z)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-6-iodo-2-methyl-hexa-1,5-dienyl]-2-methyl-thiazole 

Downstream Products

• 297131-80-7 Acetic acid (Z)-(1S,8S,9S,10R,11R)-9-benzyloxy-11-(tert-butyl-dimethyl-silanyloxy)-13-hydroxy-8,10,12,12-tetramethyl-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-tridec-3-enyl ester 
• 152044-53-6 epithilone A 
• 186692-73-9 desoxyepothilone A 

Relevant academic research and scientific papers

Methodology based on chiral silanes in the synthesis of polypropionate-derived natural products - Total synthesis of epothilone A

Epothilones A and B (1 and 2) are natural products with potent antitumor activity. These compounds have a Taxol-like mechanism of action against tumor cells. A total synthesis of epothilone A (1) is reported, which is based on the synthesis and union of t