186754-01-8

Upstream product

• 87357-76-4 (R)-3-(dodecanoyloxy)tetradecanoic acid 
• 1053628-13-9 (S)-3-((2R,3R,4R,5S,6R)-4,5-Diacetoxy-6-acetoxymethyl-3-amino-tetrahydro-pyran-2-yloxy)-2-tetradecanoylamino-propionic acid benzyl ester 
• 186753-99-1 N-tetradecanoyl-O-(3,4,6-tri-O-acetyl-2-chloroacetylamino-2-deoxy-β-D-glucopyranosyl)-L-serine benzyl ester 

Downstream Products

• 263010-78-2 Tetradecanoic acid (R)-1-({(2R,3R,4R,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[(S)-2-(2-benzyloxycarbonylamino-ethylcarbamoyl)-2-tetradecanoylamino-ethoxy]-tetrahydro-pyran-3-ylcarbamoyl}-methyl)-dodecyl ester 
• 263010-61-3 Tetradecanoic acid (R)-1-({(2R,3R,4R,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[(S)-2-(benzyloxycarbonylmethyl-carbamoyl)-2-tetradecanoylamino-ethoxy]-tetrahydro-pyran-3-ylcarbamoyl}-methyl)-dodecyl ester 
• 263010-59-9 Tetradecanoic acid (R)-1-({(2R,3R,4R,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[(S)-2-((S)-1-benzyloxycarbonyl-ethylcarbamoyl)-2-tetradecanoylamino-ethoxy]-tetrahydro-pyran-3-ylcarbamoyl}-methyl)-dodecyl ester 
• 263010-60-2 Tetradecanoic acid (R)-1-({(2R,3R,4R,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[(S)-2-((R)-1-benzyloxycarbonyl-ethylcarbamoyl)-2-tetradecanoylamino-ethoxy]-tetrahydro-pyran-3-ylcarbamoyl}-methyl)-dodecyl ester 
• 197663-31-3 N-tetradecanoyl-O-<3,4,6-tri-O-acetyl-2-deoxy-2-<(R)-3-tetradecanoyloxytetradecanoylamino>-β-D-glucopyranosyl>-L-seryl-β-alanine benzyl ester 
• 197663-09-5 N-tetradecanoyl-O-<2-deoxy-2-<(R)-3-tetradecanoyloxytetradecanoylamino>-β-D-glucopyranosyl>-L-seryl-β-alanine 

Relevant academic research and scientific papers

Lipid a and related compounds. XXXVII. Determination of favorable binding linkages of lipid a analog to antigen moiety for synthetic vaccines

For the determination of favorable binding linkages of lipid A analog as a synthetic immunoadjuvant to the antigen moiety for synthetic vaccines, new N-acylated L-serine-containing D-glucosamine analogs (Type A, B, C) were synthesized and their mitogenici

Lipid A and related compounds. XXXI. Synthesis of biologically active N-acylated L-serine-containing D-glucosamine 4-phosphate derivatives of lipid A

New N-acylated L-serine-containing non-phosphorylated and phosphorylated D-glucosamine derivatives structurally corresponding to the lipid A disaccharide backbone were synthesized. Compounds 2, 4 and 5 exhibited potent mitogenic activity. Further, compound 5 showed nitric oxide (NO) productivity.