197663-31-3Relevant articles and documents
Lipid a and related compounds. XXXVII. Determination of favorable binding linkages of lipid a analog to antigen moiety for synthetic vaccines
Ikeda, Kiyoshi,Miyajima, Keisuke,Shimizu, Tadayori,Achiwa, Kazuo
, p. 32 - 40 (2007/10/03)
For the determination of favorable binding linkages of lipid A analog as a synthetic immunoadjuvant to the antigen moiety for synthetic vaccines, new N-acylated L-serine-containing D-glucosamine analogs (Type A, B, C) were synthesized and their mitogenici
Synthesis of Tn, sialyl Tn and HIV-1-derived peptide antigen conjugates having a lipid a analog as an immunoadjuvant for synthetic vaccines
Miyajima, Keisuke,Nekado, Takahiro,Ikeda, Kiyoshi,Achiwa, Kazuo
, p. 1676 - 1682 (2007/10/03)
Conjugates (3-5) of Tn, sialyl Tn and HIV-1-derived peptide antigen with a N-tetradecanoyl L-serine-β-alanine-containing D-glucosamine derivative, structurally related to lipid A, as an immunoadjuvant for the development of totally synthetic vaccines against cancers or HIV were synthesized. The mitogenic activity of compounds 3, 4 and 5 was stronger than that of lipid A analogs (1, 2).
Synthesis of Tn, and sialyl Tn antigen-lipid a analog conjugates for synthetic vaccines
Miyajima, Keisuke,Nekado, Takahiro,Ikeda, Kiyoshi,Achiwa, Kazuo
, p. 1544 - 1546 (2007/10/03)
Conjugates of Tn and sialyl Tn antigen with N-teradecanoyl L-seryl-β- alanine-containing 9-glucosamine derivatives structurally related to lipid A as a immunoadjuvant were synthesized for the development of totally synthetic vaccines against cancers or HIV.