197663-31-3

Upstream product

• 27019-47-2 β-alanine benzyl ester p-toluenesulfonate 
• 186753-98-0 N-tetradecanoyl-O-[3,4,6-tri-O-acetyl-2-deoxy-2-[(R)-3-tetradecanoyloxytetradecanoylamino]-β-D-glucopyranosyl]-L-serine 
• 87357-76-4 (R)-3-(dodecanoyloxy)tetradecanoic acid 
• 1053628-13-9 (S)-3-((2R,3R,4R,5S,6R)-4,5-Diacetoxy-6-acetoxymethyl-3-amino-tetrahydro-pyran-2-yloxy)-2-tetradecanoylamino-propionic acid benzyl ester 
• 186754-01-8 N-tetradecanoyl-O-[3,4,6-tri-O-acetyl-2-deoxy-2-[(R)-3-tetradecanoyloxytetradecanoylamino]-β-D-glucopyranosyl]-L-serine benzyl ester 

Downstream Products

• 197663-09-5 N-tetradecanoyl-O-<2-deoxy-2-<(R)-3-tetradecanoyloxytetradecanoylamino>-β-D-glucopyranosyl>-L-seryl-β-alanine 

Relevant academic research and scientific papers

Lipid a and related compounds. XXXVII. Determination of favorable binding linkages of lipid a analog to antigen moiety for synthetic vaccines

For the determination of favorable binding linkages of lipid A analog as a synthetic immunoadjuvant to the antigen moiety for synthetic vaccines, new N-acylated L-serine-containing D-glucosamine analogs (Type A, B, C) were synthesized and their mitogenici

Synthesis of Tn, sialyl Tn and HIV-1-derived peptide antigen conjugates having a lipid a analog as an immunoadjuvant for synthetic vaccines

Conjugates (3-5) of Tn, sialyl Tn and HIV-1-derived peptide antigen with a N-tetradecanoyl L-serine-β-alanine-containing D-glucosamine derivative, structurally related to lipid A, as an immunoadjuvant for the development of totally synthetic vaccines against cancers or HIV were synthesized. The mitogenic activity of compounds 3, 4 and 5 was stronger than that of lipid A analogs (1, 2).

Synthesis of Tn, and sialyl Tn antigen-lipid a analog conjugates for synthetic vaccines

Conjugates of Tn and sialyl Tn antigen with N-teradecanoyl L-seryl-β- alanine-containing 9-glucosamine derivatives structurally related to lipid A as a immunoadjuvant were synthesized for the development of totally synthetic vaccines against cancers or HIV.