186766-21-2Relevant academic research and scientific papers
Reaction of 3-Hydroxy-1,2,3,4-tetrahydroquinoline-2,4-diones with Ethyl(Triphenylphosphoranylidene)acetate
Kafka, Stanislav,Kovar, Michal,Klasek, Antonin,Kappe, Thomas
, p. 1977 - 1982 (1996)
The Wittig reaction of 3-hydroxy-1,2,3,4-tetrahydroquinoline-2,4-diones 2 with ethyl (triphenyl-phosphoranylidene)acetate 3 proceeds stereoselectively to give E-4-carbethoxymethylene-1,2,3,4-tetrahydro-2-quinolones 4, which were hydrolyzed to corresponding acids 6. Butenolides 5 were detected and, in some cases, isolated as a minor product of the Wittig reaction.
