18679-04-4

Basic information

• Product Name: Octadecanoic acid, 3-hydroxy-2-methoxypropyl ester
• CAS NO: 18679-04-4
• Molecular Formula: C22H44O4
• Mol File: 18679-04-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Octadecanoic acid, 3-hydroxy-2-methoxypropyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Octadecanoic acid, 3-hydroxy-2-methoxypropyl ester(18679-04-4)
• EPA Substance Registry System: Octadecanoic acid, 3-hydroxy-2-methoxypropyl ester(18679-04-4)

Safety Data

• Hazardous Substances Data: 18679-04-4(Hazardous Substances Data)

Upstream product

• 57-11-4 stearic acid 
• 22610-63-5 octadecanoic acid 2,3-dihydroxypropyl ester 
• 1232676-42-4 C₂₈H₅₈O₄Si 
• 132679-65-3 1-stearoyI-3-(tert-butyldimethylsilyl)-sn-glycerol 
• 761-06-8 2-methylglycerol 
• 112-76-5 Stearoyl chloride 

Relevant articles and documents

The chemical synthesis and preliminary biological studies of phosphodiester and phosphorothioate analogues of 2-methoxy-lysophosphatidylethanolamine

The chemical synthesis of phosphorothioate/phosphodiester analogues of 2-methoxy-lysophosphatidylethanolamine has been described. For the preparation of phosphorothioate derivatives oxathiaphospholane approach has been employed. The phosphodiester compounds were prepared by OXONE oxidation of corresponding phosphorothioates. Each lysophospholipid analogue was synthesized as a series of four compounds, bearing different fatty acid residues both saturated (14:0, 16:0, 18:0) and unsaturated (18:1). The methylation of glycerol 2-hydroxyl function was applied in order to increase the stability of prepared analogues by preventing 1→2 acyl migration. The cytotoxicity of newly synthesized 2-methoxy-lysophosphatidylethanolamine derivatives was evaluated with resazurin-based method in prostate cancer PC3 cell line. The highest reduction of cell viability was noted for LPE analogues containing myristoyl acyl chain.

The chemical synthesis of metabolically stabilized 2-OMe-LPA analogues and preliminary studies of their inhibitory activity toward autotaxin

The chemical synthesis of five new metabolically stabilized 2-OMe-LPA analogues (1a-e) possessing different fatty acid residues has been performed by phosphorylation of corresponding 1-O-acyl-2-OMe-glycerols which were prepared by multistep process from racemic glycidol. The now analogues were subjected to biological characterization as autotaxin inhibitors using the FRET-based, synthetic ATX substrate FS-3. Among tested compounds 1-O-oleoyl-2-OMe-LPA (1e) appeared to be the most potent, showing ATX inhibitory activity similar to that of unmodified 1-O-oleoyl-LPA. Parallel testing showed, that similar trend was also observed for corresponding 1-O-acyl-2-OMe-phosphorothioates (2a-e, synthesized as described by us previously). 1-O-oleoyl-2-OMe-LPA (1e) was found to be resistant toward alkaline phosphatase as opposed to unmodified 1-O-oleoyl-LPA.

Hair growers

The present invention provides a hair growth promoting composition having an excellent hair growth promoting effect. The hair promoting composition comprises, as an effective ingredient, a composition expressed by following Formula (I): wherein one of R1 to R4 is selected from a group of C14-22 alkyl, C14-22 alkoxy and C14-22 acyloxy groups, and the others are selected from a group of H, OH, C1-3 alkyl and C1-3 alkoxy groups; and when R1 is C14-22 alkoxy group and one of R2 and R4 is C1-3 alkoxy group, R3 is H, C1-3 alkyl or C1-3 alkoxy group; and when R1 is C14-22 acyloxy group, at least one of R2 to R4 is C1-3 alkoxy group.