761-06-8

Upstream product

• 56-81-5 glycerol 
• 99586-36-4 5-methoxy-1,3-dioxane 
• 7647-01-0 hydrogenchloride 
• 103797-30-4 5-methoxy-2-(4-nitro-phenyl)-[1,3]dioxane 
• 104216-84-4 5-methoxy-2-phenyl-1,3-dioxane 
• 97924-47-5 2-methoxy-1,3-bis-trityloxy-propane 
• 10035-10-6 hydrogen bromide 
• 64-19-7 acetic acid 
• 71-43-2 benzene 
• 77-78-1 dimethyl sulfate 
• 67-56-1 methanol 
• 556-52-5 oxiranyl-methanol 

Downstream Products

• 68755-18-0 5-methoxytrimethylenephosphoric acid phenyl ester 
• 18679-04-4 rac.-1-Stearoyl-glycerin-methylaether-2 
• 106382-18-7 2-O-Methyl-1,3-di-O-p-phenylazobenzoyl-glycerin 
• 126953-08-0 (S)-1-O-acetyl-2-O-methylglycerol 
• 128188-17-0 (R)-1-O-acetyl-2-O-methylglycerol 
• 73757-48-9 5-Methoxy-2-phenoxy-[1,3,2]dioxaphosphinane 2-oxide 
• 73757-47-8 5-Methoxy-2-phenoxy-[1,3,2]dioxaphosphinane 2-oxide 
• 84337-41-7 3-(hexadecyloxy)-2-methoxy-1-propanol 
• 84337-43-9 2-methoxy-3-octadecyloxy-1-propanol 
• 103797-30-4 5-methoxy-2-(4-nitro-phenyl)-[1,3]dioxane 
• 20637-49-4 1,2,3-trimethoxy glycerol ether 
• 128420-67-7 1,3-O-diphenyloxycarbonyl-2-O-methylglycerol 
• 1073630-78-0 (+/-)-2-methoxy-3-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}propan-1-ol 

Relevant academic research and scientific papers

Regioselective Ring-Opening of Glycidol to Monoalkyl Glyceryl Ethers Promoted by an [OSSO]-FeIII Triflate Complex

A FeIII-triflate complex, bearing a bis-thioether-di-phenolate [OSSO]-type ligand, was discovered to promote the ring-opening of glycidol with alcohols under mild reaction conditions (0.05 mol % catalyst and 80 °C). The reaction proceeded with high activity (initial turnover frequency of 1680 h?1 for EtOH) and selectivity (>95 %) toward the formation of twelve monoalkyl glyceryl ethers (MAGEs) in a regioselective fashion (84–96 % yield of the non-symmetric regioisomer). This synthetic approach allows the conversion of a glycerol-derived platform molecule (i.e., glycidol) to high-value-added products by using an Earth-crust abundant metal-based catalyst.

Optimization of the synthesis of glycerol derived monoethers from glycidol by means of heterogeneous acid catalysis

We present an efficient and green methodology for the synthesis of glycerol monoethers, starting from glycidol and different alcohols, by means of heterogeneous acid catalysis. A scope of Br?nsted and Lewis acid catalysts were applied to the benchmark reaction of glycidol and methanol. The selected catalysts were cationic exchangers, such as Nafion NR50, Dowex 50WX2, Amberlyst 15 and K10-Montmorillonite, both in their protonic form and exchanged with Al(III), Zn(II) and Fe(III). Thus, total conversions were reached in short times by using 1 and 5% mol catalyst loading and room temperature, without the need for excess glycidol or the presence of a solvent. Finally, these conditions and the best catalysts were successfully applied to the reaction of glycidol with several alcohols such as butanol or isopropanol.

Synthesis of Monoalkyl Glyceryl Ethers by Ring Opening of Glycidol with Alcohols in the Presence of Lewis Acids

The present work deals with the production of monoalkyl glyceryl ethers (MAGEs) through a new reaction pathway based on the reaction of glycidol and alcohols catalyzed by Lewis acid-based catalysts. Glycidol is quantitatively converted with high selectivity (99 %) into MAGEs under very mild reaction conditions (80 °C and 0.01 mol % catalyst loading) in only 1 h using Al(OTf)3 or Bi(OTf)3 as catalyst. The proposed method enhances the choice of possible green synthetic approaches for the production of value-added products such as MAGEs.

MIL-101-SO3H: A highly efficient Bronsted acid catalyst for heterogeneous alcoholysis of epoxides under ambient conditions

For the first time, a ～100% sulfonic acid functionalized metal-organic framework (MOF), MIL-101-SO3H, with giant pores has been prepared by a hydrothermal process followed by a facile postsynthetic HCl treatment strategy. The replete readily accessible Lewis acidic and especially Bronsted acidic sites distributed throughout the framework as well as high stability endow the resultant MOF exceptionally high efficiency and recyclability, which surpass all other MOF-based catalysts, for the ring opening of epoxides with alcohols (especially, methanol) as nucleophiles under ambient conditions.

Graphene oxide as an acid catalyst for the room temperature ring opening of epoxides

The minute amount of hydrogen sulfate groups introduced into the graphene oxide (GO) obtained by Hummers oxidation of graphite renders this material as a highly efficient, recyclable acid catalyst for the ring opening of epoxides with methanol and other primary alcohols as nucleophile and solvent.

Optimization of synthesis of mono-O-methylglycerol isomers

Parameters were refined for synthesis of glycerol 1-monomethyl ether by methylation of glycerol with dimethyl sulfate in the presence of alkali; a gas-liquid chromatographic procedure was proposed for identification of structural isomers of mono-O-methylglycerol.