186795-56-2Relevant academic research and scientific papers
Synthesis of a cisplatin derivative from lithocholic acid
Hryniewicka, Agnieszka,?otowski, Zenon,Seroka, Barbara,Witkowski, Stanis?aw,Morzycki, Jacek W.
, p. 5392 - 5398 (2018/02/12)
A new steroidal-platinum(II) hybrid compound was synthesized using a simple and efficient methodology. The synthesis was performed by a convergent approach with cross metathesis (CM) as a key step. An olefin derived from lithocholic acid and a vinyl substituted ethylenediamine derived from L-serine were used as chiral building blocks, which were combined in the CM step. The most important advantage of this method was the utilization of L-serine as a cheap, stereoisomerically pure substrate. A steroid with a diamino system in the side chain was subjected to reaction with potassium tetrachloroplatinate to obtain the target platinum(II) complex. Attempts to synthesize similar diamine systems using the asymmetric Strecker reaction were unsuccessful.
Rapid organocatalytic aldehyde-aldehyde condensation reactions
Erkkilae, Anniina,Pihko, Petri M.
, p. 4205 - 4216 (2008/03/14)
We report the results of the systematic optimization of the α-methylenation of aldehydes with aqueous formaldehyde. A simple combination of a secondary amine catalyst and a weak acid co-catalyst has been identified, allowing access to α-substituted acroleins in a matter of minutes. In the absence of formaldehyde, the catalytic system promoted the self-condensation reaction of α,β-unsaturated aldehydes. Both of these reactions exhibited linear relationships between co-catalyst acidities and reaction rates. A second-order dependence of catalyst concentration was observed, pointing to the involvement of two molecules of the ammonium catalyst in the rate-determining step. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.
Mild organocatalytic α-methylenation of aldehydes
Erkkil?, Anniina,Pihko, Petri M.
, p. 2538 - 2541 (2007/10/03)
A rapid and extremely convenient method for α-methylenation of aldehydes with aqueous formaldehyde is described. Two optimal catalytic systems are presented that allow short reaction times and afford the functionalized products in good to excellent yields (up to 99%) and chemoselectivity.
An efficient synthesis of 6-substituted aminohexahydro-1H-1,4-diazepines from 2-substituted aminopropenals
Harada, Hiroshi,Morie, Toshiya,Hirokawa, Yoshimi,Kato, Shiro
, p. 2205 - 2212 (2007/10/03)
Swern oxidation of 2-substituted amino-1,3-propanediols 20a - d, 38, 41, and 42 smoothly proceeded to give the oxidative dehydration products, 2-substituted aminopropenals 17a - d, 43, 45 and 46, respectively. Reaction of the intriguing 2-substituted amin
