186809-64-3

Upstream product

• 1193-62-0 methyl Pyrrole-2-carboxylate 
• 613-92-3 N-hydroxyl-benzamidine 
• 1003-29-8 2-pyrrole aldehyde 
• 613-92-3 N-hydroxybenzenecarboximidamide 

Downstream Products

• 186809-65-4 4-Acetyl-3-methyl-5-[5-(3-phenyl-[1,2,4]oxadiazol-5-yl)-1H-pyrrol-2-ylmethyl]-1H-pyrrole-2-carboxylic acid ethyl ester 
• 186809-90-5 1-{4-Methyl-5-(3-phenyl-[1,2,4]oxadiazol-5-yl)-2-[5-(3-phenyl-[1,2,4]oxadiazol-5-yl)-1H-pyrrol-2-ylmethyl]-1H-pyrrol-3-yl}-ethanone 

Relevant academic research and scientific papers

Synthesis of 3,5-Disubstituted 1,2,4-Oxadiazoles from Amidoximes and Aldehydes in the Superbasic System NaOH/DMSO

Abstract: A new procedure has been proposed for the synthesis of 3,5-disubstituted 1,2,4-oxadiazoles by reaction of amidoximes with aldehydes in the superbasic system NaOH/DMSO at room temperature. The scope of the proposed procedure has been demonstrated by 15 syntheses from various amidoximes and aromatic aldehydes with 27–76% yields. The procedure is inapplicable to aliphatic aldehydes.

The first one-pot ambient-temperature synthesis of 1,2,4-oxadiazoles from amidoximes and carboxylic acid esters

The first one-pot room-temperature protocol for the synthesis of 3,5-disubstituted-1,2,4-oxadiazoles via the condensation between amidoximes and carboxylic acid esters in superbase medium MOH/DMSO is reported. A broad spectrum of alkyl, aryl and hetaryl amidoximes and esters was examined. This reaction route provides convenient access to 1,2,4-oxadiazoles, which is highly desirable because in the light of this privileged scaffold is recognized as an important core in the design of novel therapeutic agents and high-tech materials.