169552-95-8

Upstream product

• 186817-88-9 (R)-2-Diazo-3-oxo-4-[(2R,3S)-4-oxo-3-((R)-1-triethylsilanyloxy-ethyl)-azetidin-2-yl]-pentanoic acid 4-nitro-benzyl ester 
• 186817-91-4 (4R,5R,6S)-4-methyl-3,7-dioxo-6-((1'R)-triethylsilanyloxy-ethyl)-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 4-nitro-benzyl-ester 
• 157700-96-4 6-Bromo-2-methoxymethyl-fluoren-9-one 
• 136682-17-2 6-Bromo-2-bromomethyl-9-fluorenone 
• 136682-02-5 3-bromo-7-hydroxymethyl-9-fluorenone 
• 154428-43-0 (4R,5R,6S)-6-((R)-1-Hydroxy-ethyl)-4-methyl-7-oxo-3-trifluoromethanesulfonyloxy-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 137154-53-1 3-bromo-7-methyl-9-fluorenone 
• 91713-57-4 (2-amino-5-methylphenyl)(4-bromophenyl)methanone 
• 90822-24-5 (γR,2R,3S)-α-diazo-3-[(1R)-1-hydroxyethyl]-γ-methyl-β,4-dioxo-2-azetidinebutanoic acid (4-nitrophenyl)methyl ester 
• 104873-15-6 4-nitrobenzyl (4R,5R,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-3,7-dioxo-1-azabicyclo[3.2.0]-heptane-2-carboxylate 
• 106-49-0 p-toluidine 
• 623-00-7 4-bromobenzenecarbonitrile 
• 994-30-9 triethylsilyl chloride 
• 10416-59-8 N,O-bis-(trimethylsilyl)-acetamide 

Downstream Products

• 212691-56-0 (4S,5R,6S)-4-Methyl-7-oxo-3-[9-oxo-7-(propane-1-sulfonyloxymethyl)-9H-fluoren-3-yl]-6-((R)-1-triethylsilanyloxy-ethyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 157743-80-1 (4S,5R,6S)-3-(7-Hydroxymethyl-9-oxo-9H-fluoren-3-yl)-4-methyl-7-oxo-6-((R)-1-triethylsilanyloxy-ethyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 

Relevant academic research and scientific papers

Practical synthesis of anti-methicillin-resistant Staphylococcus aureus (MRSA) carbapenem L-742,728

Anti-MRSA carbapenem, L-742,728, has been prepared in large quantity using the Suzuki-Miyaura cross-coupling as the key reaction. Three approaches have been examined by varying the coupling reaction between carbapenem nucleus A and side chains B, BC, and