186818-93-9Relevant academic research and scientific papers
Convenient Access to 2,3-Disubstituted-cyclobut-2-en-1-ones under Suzuki Conditions and Their Synthetic Utility
Alcaide, Benito,Almendros, Pedro,Lázaro-Milla, Carlos
, p. 7547 - 7552 (2019/04/30)
A regioselective synthesis of general applicability has been designed for the one-pot preparation of 2,3-disubstituted-cyclobutenones from iodoalkynes through cyclobutenylation, Suzuki CC coupling, and ketone formation. This one-pot methodology has been a
Novel 1,2-diarylcyclobutenes: Selective and orally active COX-2 inhibitors
Friesen, Richard W.,Dube, Daniel,Fortin, Rejean,Frenette, Richard,Prescott, Sylvie,Cromlish, Wanda,Greig, Gillian M.,Kargman, Stacia,Wong, Elizabeth,Chan, Chi Chung,Gordon, Robert,Xu, Li Jing,Riendeau, Denis
, p. 2677 - 2682 (2007/10/03)
A series of novel 2,3-diaryl-2-cyclobuten-1-ones have been synthesized and have been evaluated with respect to their ability to inhibit the isozymes of cyclooxygenase, COX-1 and COX-2. 4,4-Dimethyl-2-phenyl-3-[4-(methylsulfonyl)phenyl]cyclobutenone 22 was found to be highly selective for inhibition of COX-2 and was orally active (ED50 = 2.4 mg/kg) in the rat paw edema model.
