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Usage

Uses

Used in Rubber and Polymer Production:
2,4-DIAMINO-6-[4-(TRIFLUOROMETHYL)PHENYL]-1,3,5-TRIAZINE is used as a cross-linking agent in the vulcanization process for improving the mechanical properties of rubber, such as its strength and durability. This application is crucial for the production of high-quality rubber goods that are resistant to wear and tear.
Used as a Chemical Intermediate:
In the synthesis of other organic compounds, 2,4-DIAMINO-6-[4-(TRIFLUOROMETHYL)PHENYL]-1,3,5-TRIAZINE serves as a valuable chemical intermediate. Its reactivity and structural properties make it a key component in the creation of a variety of chemical products, contributing to the diversity of applications in different industries.

InChI:InChI=1/C10H8F3N5/c11-10(12,13)6-3-1-5(2-4-6)7-16-8(14)18-9(15)17-7/h1-4H,(H4,14,15,16,17,18)

Upstream product

• 455-18-5 4-CF₃C₆H₄CN 
• 127099-85-8 N-Cyanoguanidine 

Relevant academic research and scientific papers

Synthesis, molecular docking studies, and in vitro evaluation of 1,3,5-triazine derivatives as promising antimicrobial agents

The six-membered ring heterocycle 1,3,5-triazine and its derivatives have attracted considerable attention as they have proven to be excellent bioactive herbicides, cancer agents, etc. A series of 1,3,5-triazine derivatives (3a-o) were synthesized by a single step reaction and characterized by 1H NMR, 13C NMR, and mass spectrometry analysis. Antimicrobial screening of title compounds (3a-o) was examined against five bacterial and two fungal strains. In vitro study revealed that the freshly synthesized 6-(thiazol-4-yl)-1,3,5-triazine-2,4-diamine (3o) showed good antibacterial growth inhibition against E. coli, K. pneumoniae, and A. baumannii bacterial strains, and even the fungi C. neoformans. Molecular docking studies were performed on the X-ray crystal structure of E. coli 24 kDa domain in complex with clorobiocin (PDB code: 1KZN; resolution 2.30 ?) using Surflex-Dock program of Sybyl-X software. The results obtained are very encouraging.

2,4,6-trisubstituted-1,3,5-s-triazine compound and preparation and application thereof

The invention provides a 2,4,6-trisubstituted-1,3,5-s-triazine compound as well as preparation and application thereof, and biguanide or dimethyl biguanide hydrochloride is used as an initial raw material to react with a cyano compound under an alkaline condition to prepare the 2,4,6-trisubstituted-1,3,5-s-triazine compound. The invention provides a simple and convenient synthetic method of a 2,4,6-trisubstituted-1,3,5-s-triazine compound, and the compound provided by the invention can be applied to preparation of an anti-myelogenous leukemia medicine, namely an enasidenib medicine. Compared with the prior art, the method for preparing the enasidenib has the advantages that two-step reaction is reduced, the use of a halogenating reagent is avoided, and the method is a green and environment-friendly chemical process. The structural formula I is shown in the specification.

Model Systems for Flavoenzyme Activity. Regulation of Flavin Recognition via Modulation of Receptor Hydrogen-Bond Donor-Acceptor Properties

We have synthesized a new family of receptors for flavins based on 6-aryl-2,4-(acyldiamino)-s-triazines. In these synthetic hosts, systematic variation of the spatially remote substituents on the 6-aryl ring alters the hydrogen-bond-donating abilities of the amide functionality and the hydrogen-bond-accepting properties of the triazine N(3). This variation results in a strong modulation of the efficiency of flavin binding, with association constants for the receptor flavin complexes ranging over an 8-fold range.