186884-24-2

Upstream product

• 855-38-9 P(p-CH₃OC₆H₄)3 
• 96029-36-6 chloro[tris(para-methoxyphenyl)phosphine]gold(I) 
• 7550-35-8 lithium bromide 

Relevant academic research and scientific papers

Gold(i) and gold(iii) phosphine complexes: synthesis, anticancer activities towards 2D and 3D cancer models, and apoptosis inducing properties

A series of gold(i), gold(iii) and cationic gold(i) complexes of tris(4-methoxyphenyl)phosphine and tris(2,6-dimethoxyphenyl)phosphine were synthesised and fully characterised by spectroscopic methods. The molecular structures of selected complexes were also determined by X-ray diffraction analysis. The prepared complexes [AuX{P(C6H4-4-OMe)3}] [X = Cl (1), Br (2), I (3)], [AuCl3{P(C6H4-4-OMe)3}] (4), [Au{P(C6H4-4-OMe)3}2]PF6 (5), [AuX{P(C6H3-2,6-{OMe}2)3}] [X = Cl (6), Br (7), I (8)], [AuCl3{P(C6H3-2,6-{OMe}2)3}] (9) and [Au{P(C6H3-2,6-{OMe}2)3}2]PF6 (10) were investigated for their anticancer activity against five human tumor cell lines [ovarian (SKOV-3), fibrosarcoma (HT1080), glioblastoma (U87MG), prostate (PC-3), and cervical (HeLa)] as well as against 3D spheroidal models of HeLa cells. The cationic complex 10 was found to exhibit a remarkably broad spectrum of anticancer activity with approximately 30-fold higher toxicity than cisplatin against PC-3 and U87MG cancer cells; this complex also showed the strongest inhibition of spheroid growth in 3D models of HeLa cells. The mechanism of anticancer activity of these gold complexes was found to be strong inhibition of thioredoxin reductase, increased ROS production and subsequent apoptosis induction as evidenced by the sub G1 cell accumulation, DNA fragmentation, and caspase-3 activation.

Structural studies of two-coordinate complexes of tris(2-methoxylphenyl)phosphine and tris(4-methoxyphenyl)phosphine with gold(I) halides

A series of five gold(I) halide complexes with the two isomeric methoxy-substituted triarylphosphines, tris(2-methoxyphenyl)phosphine [P(oanis)3], [AuP(oanis)3X] [for X = Cl, (1); X = Br, (2) and X = I, (3)] and tris(4-methoxyphenyl)phosphine [P(panis)3], [AuP(panis)3X] [for X = Br (4) and X = I (5)] have been synthesized and characterized by single crystal X-ray diffraction and solution 31P{1H} NMR spectroscopy. The structure determinations confirm the expected presence of linear two-coordination about the gold centres in all five complexes with bond distance and angle data typical of this type of compound [Au-P, 2.239(2)-2.259(3) ?; Au-Cl, 2.294(2) ?; Au-Br, 2.385(2)-2.402(2) ?; Au-I, 2.546(1)-2.554(1) ?; P-Au-X; 175.3(1)-180°]. All analogues except the iodo complex 5 crystallize with one complex molecule in the crystallographic asymmetric unit. The bromo and iodo complexes 2 and 3 constitute a trigonal isomorphous set while the bromo complex 4 is also isomorphous with the previously determined chloro complex [AuP(panis)3Cl]. The 2-methoxy analogues are stabilized by significant methoxy-O?Au interactions.