186895-55-6Relevant articles and documents
Efficient and selective synthesis of 6,7-dehydrostipiamide via Zr-catalyzed asymmetric carboalumination and Pd-catalyzed cross-coupling of organozincs
Zeng, Xingzhong,Zeng, Fanxing,Negishi, Ei-Ichi
, p. 3245 - 3248 (2007/10/03)
(Chemical Equation Presented) 6,7-Dehydrostipiamide has been synthesized in 23% yield in 15 steps in the longest linear sequence through the application of the Zr-catalyzed asymmetric carboalumination and the Pd-catalyzed organozinc cross-coupling in addi
Total synthesis of stipiamide and designed polyenes as new agents for the reversal of multidrug resistance
Andrus, Merritt B.,Lepore, Salvatore D.,Turner, Timothy M.
, p. 12159 - 12169 (2007/10/03)
The synthesis of (-)-stipiamide (1) is reported together with the designed enynes 2 (6,7-dehydrostipiamide) and 3 that are now shown to reverse the multidrug resistance (MDR) of human breast cancer cells (MCF-7adrR). Stipiamide was assembled using a Still