186895-56-7Relevant articles and documents
Efficient and selective synthesis of 6,7-dehydrostipiamide via Zr-catalyzed asymmetric carboalumination and Pd-catalyzed cross-coupling of organozincs
Zeng, Xingzhong,Zeng, Fanxing,Negishi, Ei-Ichi
, p. 3245 - 3248 (2007/10/03)
(Chemical Equation Presented) 6,7-Dehydrostipiamide has been synthesized in 23% yield in 15 steps in the longest linear sequence through the application of the Zr-catalyzed asymmetric carboalumination and the Pd-catalyzed organozinc cross-coupling in addi
Synthesis of a C-9 to C-18 building block of the phenalamides
Hoffmann, Reinhard W.,Haeberlin, Eckart,Rohde, Thorsten
, p. 207 - 212 (2007/10/03)
In the context of a synthesis of phenalamide A2, the C-9 to C-18 building block 6 was synthesized. The stereogenic centers were generated by alkylation of an Evans oxazolidinone 12 and by a crotylboration reaction using the enantiomerically pure (E)-α-chlorocrotylboronate (4).
Total synthesis of phenalamide A2
Hoffmann, Reinhard W.,Rohde, Thorsten,Haeberlin, Eckart,Sch?fer, Frank
, p. 1713 - 1715 (2008/02/11)
(formula presented) Phenalamide A2 (1b) has been synthesized for the first time. The synthesis features the homologation of aldehyde 5 to trienal 3 with the new conjunctive reagent 6 and the formation of amide 14 with the functionalized Horner-
Total synthesis of stipiamide and designed polyenes as new agents for the reversal of multidrug resistance
Andrus, Merritt B.,Lepore, Salvatore D.,Turner, Timothy M.
, p. 12159 - 12169 (2007/10/03)
The synthesis of (-)-stipiamide (1) is reported together with the designed enynes 2 (6,7-dehydrostipiamide) and 3 that are now shown to reverse the multidrug resistance (MDR) of human breast cancer cells (MCF-7adrR). Stipiamide was assembled using a Still
