1869-45-0Relevant articles and documents
A reactive oxygen species (ROS)-responsive polymer for safe, efficient, and targeted gene delivery in cancer cells
Shim, Min Suk,Xia, Younan
, p. 6926 - 6929 (2013)
Stimuli-responsive release: The high levels of reactive oxygen species (ROS) in prostate cancer cells can be exploited to trigger cancer-targeted gene delivery. A ROS-responsive thioketal-based cationic polymer was synthesized and functionalization with a cancer-targeting peptide led to selective and enhanced gene transfection in prostate cancer cells (see scheme). Copyright
Synthesis of a reactive oxygen species-responsive doxorubicin derivative
Delehanty, James B.,Das, Shivani,Goldberg, Efram,Sangtani, Ajmeeta,Knight, D. Andrew
, (2018)
A heterobifunctional reactive oxygen species (ROS)-responsive linker for directed drug assembly onto and delivery from a quantum dot (QD) nanoparticle carrier was synthesized and coupled to doxorubicin using N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (EDC)/sulfo–NHS coupling. The doxorubicin conjugate was characterized using 1H NMR and LC-MS and subsequently reacted under conditions of ROS formation (Cu2+/H2O2) resulting in successful and rapid thioacetal oxidative cleavage, which was monitored using 1H NMR.
Thioketal connection unit, synthetic method and purpose thereof
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Paragraph 0065; 0066; 0067, (2017/01/02)
The invention discloses a thioketal connection unit, a synthetic method and a purpose thereof. The thioketal connection unit has a structure shown as a formula (I) in the specification, wherein, R=-OH or -COOH; R1 and R2 can satisfy one of the following c