186903-53-7

Upstream product

• 146501-55-5 (R)-methyl 4-[(tert-butyloxycarbonyl)amino]-6-methylheptanoate 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 186903-43-5 (R)-2-[(R)-3-Phenyl-2-(2,2,2-trifluoro-acetylamino)-propyl]-pent-4-enoic acid methyl ester 
• 186903-46-8 (E)-(R)-5-Phenyl-2-[(R)-3-phenyl-2-(2,2,2-trifluoro-acetylamino)-propyl]-pent-4-enoic acid methyl ester 
• 186903-45-7 (2R,4R)-2-Methyl-5-phenyl-4-(2,2,2-trifluoro-acetylamino)-pentanoic acid methyl ester 
• 186903-44-6 (2R,4R)-2-Benzyl-5-phenyl-4-(2,2,2-trifluoro-acetylamino)-pentanoic acid methyl ester 

Relevant academic research and scientific papers

1,3-Asymmetric induction in enolate alkylation reactions of N-protected γ-amino acid derivatives

Dianions derived from N-TFA and N-Boc γ-amino acid esters and amides undergo highly stereoselective α-alkylation reactions. The roles of HMPA, of the cation, the electrophile, and of steric factors were studied.