1,3-Asymmetric induction in enolate alkylation reactions of N-protected γ-amino acid derivatives

Article abstract of DOI:10.1016/S0040-4039(96)02263-0

Dianions derived from N-TFA and N-Boc γ-amino acid esters and amides undergo highly stereoselective α-alkylation reactions. The roles of HMPA, of the cation, the electrophile, and of steric factors were studied.