1,3-Asymmetric induction in enolate alkylation reactions of N-protected γ-amino acid derivatives

DOI: 10.1016/S0040-4039(96)02263-0

Source and publish data:

Tetrahedron Letters p. 163 - 166 (1997)

Update date:2022-09-26

Topics:

Authors:

Hanessian, Stephen

Schaum, Robert

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Article abstract of DOI:10.1016/S0040-4039(96)02263-0

Dianions derived from N-TFA and N-Boc γ-amino acid esters and amides undergo highly stereoselective α-alkylation reactions. The roles of HMPA, of the cation, the electrophile, and of steric factors were studied.

Full text of DOI:10.1016/S0040-4039(96)02263-0

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