186961-76-2Relevant academic research and scientific papers
Peptide inhibitors of IκB protease: Modification of the C-termini of Z-LLF-CHO
Suto, Mark J.,Sullivan, Robert W.,Ransone, Lynn J.
, p. 2925 - 2930 (2007/10/03)
A series of tripeptides (Z-LLF-R) with various modifications at their C-terminus were synthesized and evaluated for their ability to prevent the activation of NF-κB through inhibition of IκB protease. Of the compounds evaluated only the C-terminal aldehydes 5a,b were active in our Jurkat T-cell based assay. Compounds 5a also decreased IL-2 and IL-8 levels in these cells indicating that inhibitors of IκB protease can have an effect on various signalling pathways.
