TAPI-2, also known as N-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide, is a hydroxamate-based inhibitor of matrix metalloproteinases (MMPs) and tumor necrosis factor-alpha converting enzyme (TACE). It plays a crucial role in the regulation of various biological processes, including cell proliferation, migration, and apoptosis.
187034-31-7
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Basic information
- Product Name: TAPI-2
- Synonyms: TAPI-2;N-(R)-[2-(HYDROXYAMINOCARBONYL)METHYL]-4-METHYLPENTANOYL-L-T-BUTYL-ALANYL-L-ALANINE, 2-AMINOETHYL AMIDE;N-(R)-(2-(HYDROXYAMINOCARBONYL)METHYL)-4-METHYLPENTANOYL-L-T-BUTYL-GLYCYL-L-ALANINE 2-AMINOETHYL AMIDE;TNF-ALPHA PROTEASE INHIBITOR-2;HONHCOCH2CH(CH2-CH(CH3)2)CO-T-LEU-ALA-NHCH2CH2NH2;N-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide;N-[2-[2-(HydroxyaMino)-2-oxoethyl]-4-Methyl-1-oxopentyl]-3-Methyl-L-valyl-N-(2-aMinoethyl)-L-alaninaMide Acetic Acid;TAPI-2 (TNF Protease Inhibitor 2)
- CAS NO:187034-31-7
- Molecular Formula: C19H37N5O5
- Molecular Weight: 415.53
- EINECS: N/A
- Product Categories: A hydroxamate-based inhibitor of MMPs and TACE.
- Mol File: 187034-31-7.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- Sensitive: Light Sensitive & Hygroscopic
- CAS DataBase Reference: TAPI-2(CAS DataBase Reference)
- NIST Chemistry Reference: TAPI-2(187034-31-7)
- EPA Substance Registry System: TAPI-2(187034-31-7)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 187034-31-7(Hazardous Substances Data)
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187034-31-7 Usage
Uses
Used in Pharmaceutical Industry:TAPI-2 is used as a TACE inhibitor for inhibiting the secretase in pig kidney microvillar membranes. Its ability to inhibit TACE makes it a potential therapeutic agent for the treatment of various diseases, including cancer and neurodegenerative disorders.
Used in Research Applications:
TAPI-2 is used as a hydroxamate-based inhibitor of MMPs and TACE in research settings. It helps researchers study the role of these enzymes in various biological processes and their potential as therapeutic targets for the development of new drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 187034-31-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,7,0,3 and 4 respectively; the second part has 2 digits, 3 and 1 respectively.Calculate Digit Verification of CAS Registry Number 187034-31:
(8*1)+(7*8)+(6*7)+(5*0)+(4*3)+(3*4)+(2*3)+(1*1)=137
137 % 10 = 7
So 187034-31-7 is a valid CAS Registry Number.
187034-31-7Upstream product
187034-31-7Downstream Products
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TAPI-2
