187038-02-4

Downstream Products

• 187038-04-6 (E)-(4R,6S)-4-Benzyloxy-2,6-dimethyl-7-oxo-hept-2-enoic acid ethyl ester 
• 147384-55-2 calbistrin A 
• 187038-09-1 (1R,2R,4aR,5R,6S,8R,8aS)-8-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-5-methoxymethoxy-1,2,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carbaldehyde 
• 187038-11-5 (1R,2R,4aR,5S,6S,8R,8aS)-8-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-5-chloro-1,2,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carbaldehyde 
• 187038-03-5 (E)-(4R,6S)-4-Benzyloxy-7,7-bis-ethylsulfanyl-2,6-dimethyl-hept-2-enoic acid ethyl ester 

Relevant academic research and scientific papers

The first total synthesis of calbistrin A, a microbial product possessing multiple bioactivities

The octahydronaphthopyranone moiety is synthesized from methyl α-D-mannopyranoside through the intramolecular Diels-Alder reaction, and the tetraenedicarboxylic acid moiety is from the enzymatically prepared anti-compound. Both moieties were coupled to accomplish the total synthesis of calbistrin A and to disclose its absolute structure.