18708-18-4

Basic information

• Product Name: Benzenesulfonic acid,4-methyl-, 2-(2-furanylmethylene)hydrazide
• Synonyms: Benzenesulfonicacid, 4-methyl-, (2-furanylmethylene)hydrazide (9CI); p-Toluenesulfonic acid,2-furfurylidenehydrazide (8CI); 4-Methylbenzenesulfonic acid(2-furanylmethylene)hydrazide; Furfural tosylhydrazone; Furfurylidenep-toluenesulphonylhydrazone; NSC 126962
• CAS NO: 18708-18-4
• Molecular Formula: C12H12 N2 O3 S
• Molecular Weight: 264.305
• Mol File: 18708-18-4.mol
• Article Data: 30

Chemical Properties

• Boiling Point: 413°Cat760mmHg
• Flash Point: 203.6°C
• Density: 1.29g/cm³
• CAS DataBase Reference: Benzenesulfonic acid,4-methyl-, 2-(2-furanylmethylene)hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonic acid,4-methyl-, 2-(2-furanylmethylene)hydrazide(18708-18-4)
• EPA Substance Registry System: Benzenesulfonic acid,4-methyl-, 2-(2-furanylmethylene)hydrazide(18708-18-4)

Safety Data

• Hazardous Substances Data: 18708-18-4(Hazardous Substances Data)

Upstream product

• 98-01-1 furfural 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 32332-98-2 3-(2-furyl)pyrazole 
• 3777-69-3 2-pentylfuran 
• 4466-24-4 2-Butylfuran 
• 3777-70-6 2-hexylfuran 
• 13466-40-5 (2E, 4E)-5-phenylpenta-2,4-dienal 
• 49678-07-1 (2E,4E)-5-(4-methoxyphenyl)penta-2,4-dienal 
• 1240042-04-9 3-[(4-bromophenoxy)methyl]furan 
• 113986-24-6 2-(furan-2-yl)-N-phenylacetamide 
• 70027-12-2 4-(5-furan-2-yl-tetrazol-2-yl)-benzoic acid 
• 55289-81-1 Furfuryl-p-toluolsulfinat 
• 5066-65-9 (E)-3-(furan-2-yl)-1-(4-methoxyphenyl)prop-2-en-1-one 
• 3663-61-4 2-amino-5-furyl-1,3,4-triazole 

Relevant articles and documents

Potassium tert -Butoxide Promoted Synthesis of 4,5-Diaryl-2 H -1,2,3-triazoles from Tosylhydrazones and Nitriles

Intermolecular cycloaddition of tosylhydrazones with nitriles was investigated. t -BuOK was shown to be an excellent base for increasing the effectiveness of the reaction in this protocol, and homocoupling of the tosylhydrazones was significantly inhibited by using xylene as a solvent. Through this transformation, a variety of 4,5-diaryl-2 H -1,2,3-triazoles were prepared in good to excellent yields and with high purities. The process is azide-free and transition-metal-free.

Diversity-Oriented Synthesis of 1,2,4-Triazols, 1,3,4-Thiadiazols, and 1,3,4-Selenadiazoles from N-Tosylhydrazones

The diversity-oriented synthesis of 1,2,4-triazols, 1,3,4-thiadiazols, and 1,3,4-selenadiazoles from N-tosylhydrazones was developed, and the reactions were general for a wide range of substrates, in which NH2CN, KOCN, KSCN, and KSeCN were used as odorless sources. Two different pathways were proposed, and N-tosylhydrazonoyl chlorides were formed in situ in the presence of NCS.

Palladium-Catalyzed Three-Component Coupling Reaction of o-Bromobenzaldehyde, N-Tosylhydrazone, and Methanol

A ligand-controlled palladium-catalyzed three-component reaction of o-bromobenzaldehyde, N-tosylhydrazone, and methanol is described. This reaction uses readily available compounds as starting materials while displaying a broad substrate scope and good functional group compatibility.