1871-72-3

Basic information

• Product Name: 1-bromo-2-fluoro-propane
• Synonyms: 1-bromo-2-fluoro-propane
• CAS NO: 1871-72-3
• Molecular Formula: C₃H₆BrF
• Molecular Weight: 140.98
• Mol File: 1871-72-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 84.2°Cat760mmHg
• Flash Point: 6°C
• Appearance: /
• Density: 1.452g/cm³
• Vapor Pressure: 81.4mmHg at 25°C
• Refractive Index: 1.405
• CAS DataBase Reference: 1-bromo-2-fluoro-propane(CAS DataBase Reference)
• NIST Chemistry Reference: 1-bromo-2-fluoro-propane(1871-72-3)
• EPA Substance Registry System: 1-bromo-2-fluoro-propane(1871-72-3)

Safety Data

• Hazardous Substances Data: 1871-72-3(Hazardous Substances Data)

Usage

Physical appearance

Colorless liquid 1-bromo-2-fluoro-propane is a colorless liquid, which means it does not have any visible color.

Flammability

Flammable This compound can easily catch fire or ignite, so it should be handled with caution and kept away from sources of heat or open flames.

Uses

Solvent, reagent in chemical reactions, organic synthesis, pharmaceuticals, and agrochemicals production 1-bromo-2-fluoro-propane serves various purposes in the chemical industry, including acting as a solvent, a reagent in different chemical reactions, and as a starting material for the synthesis of pharmaceuticals and agrochemicals.

Classification

Halogenated alkane This compound is classified as a halogenated alkane because it contains bromine and fluorine atoms bonded to a propane molecule.

Safety precautions

Hazardous material, skin and eye irritation, proper ventilation, and safety measures 1-bromo-2-fluoro-propane can cause skin and eye irritation, so it is essential to handle it with care, use it in well-ventilated areas, and follow proper safety precautions to minimize risks.

InChI:InChI=1/C3H6BrF/c1-3(5)2-4/h3H,2H2,1H3

Upstream product

• 187737-37-7 propene 
• 109-64-8 1,3-dibromo-propane 

Downstream Products

• 200557-29-5 2,2-Dimethyl-propionic acid 3-benzyl-8-cyclopentyl-1-(2-fluoro-propyl)-2,6-dioxo-1,2,3,6-tetrahydro-purin-7-ylmethyl ester 
• 106114-52-7 1-(2-fluoropropyl)-4-phenylpiperazine 

Relevant articles and documents

REACTION OF ORGANIC COMPOUNDS WITH SF4-HF-HALOGENATING SYSTEM VII. REACTIONS OF OLEFINS WITH THE SF4-HF-Cl2(Br2) SYSTEM

Under the influence of the SF4-HF-Cl2(Br2) system halogen-containing olefins undergo conjugate halogenofluorination.It was shown for the case of (Z)- and (E)- 1,2-dichloroethenes that these reactions take place anti-stereospecifically through the formation of the bromonium ions.The accumulation of chlorine atoms in the olefin molecule hinders electrophilic addition of stoichiometric equivalents of ClF and BrF at the double bond.The SF4-HF-Br2 system is an effective agent for substitutive fluorination of organic compounds containing bromine.Only the bromine atoms situated at the secondary carbon atom are substituted by fluorine.

REACTIONS OF CHLORINE MONOFLUORIDE. VI. RELATIVE RATES OF SUBSTITUTIVE FLUORINATION OF BROMINE-SUBSTITUTED ALKANES. HYDRIDE SHIFTS AND OTHER MIGRATIONS DURING FLUORINATION

The relative rates of substitutive fluorination of bromoalkanes with various structures by chlorine monofluoride in a nonpolar medium at 20-40 deg C were investigated by the method of competing reactions.Halogen atoms vicinal with the substituted bromine greatly reduce the fluorination rate.The reactivity of the secondary bromides decreases in the order (CH3)2CHBr>>CH3CHBrCH2Cl>>CH2ClCHBrCH2Cl.The geminal halogen atoms have little effect on the rate of substitutive fluorination.The fluorination rates of the bromoalkanes CH2BrCH2Br, CH2BrCHClBr, and CH2BrCCl2Br are in ratios 10:3:1 respectively, while the fluorination rate of CH3CHClBr is much higher than that of CH2ClCH2Br.As a rule the debromination of primary bromides containing vicinal halogens (Br, Cl) is accompanied by migration of the latter and gives fluorides with iso structures.Hydride shifts take place in cases where stable tertiary or secondary carbocations are formed as a result of migration of the hydride; for example, the fluorination of CH3CHFCH2Br leads to the geminal difluoroalkane CH3CF2CH3.The mechanism of substitutive fluorination is discussed.