187101-52-6

Basic information

• Product Name: 2-azido-1-(3,4-dimethoxyphenyl)ethanone
• Synonyms: 2-azido-1-(3,4-dimethoxyphenyl)ethanone
• CAS NO: 187101-52-6
• Molecular Weight: 221.216
• Mol File: 187101-52-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-azido-1-(3,4-dimethoxyphenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-azido-1-(3,4-dimethoxyphenyl)ethanone(187101-52-6)
• EPA Substance Registry System: 2-azido-1-(3,4-dimethoxyphenyl)ethanone(187101-52-6)

Safety Data

• Hazardous Substances Data: 187101-52-6(Hazardous Substances Data)

Upstream product

• 91-16-7 1,2-dimethoxybenzene 
• 1131-62-0 1-(3,4-dimethoxyphenyl)ethanone 
• 1835-02-5 2-Bromo-1-(3,4-dimethoxyphenyl)ethanone 

Downstream Products

• 947594-79-8 3,4-dimethoxyphenacyl azide ethylene ketal 
• 70216-33-0 N-(2-(3,4-dimethoxyphenyl)-2-oxoethyl)benzamide 
• 1448863-90-8 diethyl 2-(3,4-dimethoxybenzoyl)-6-(3,4-dimethoxyphenyl)pyridine-3,4-dicarboxylate 
• 1448863-89-5 dimethyl 2-(3,4-dimethoxybenzoyl)-6-(3,4-dimethoxyphenyl)pyridine-3,4-dicarboxylate 
• 1187829-40-8 (3,4-dimethoxyphenyl)(5-(3,4-dimethoxyphenyl)-1H-imidazol-2-yl)methanone 
• 1187829-40-8 (3,4‐dimethoxyphenyl)[4‐(3,4‐dimethoxyphenyl)‐1H‐imidazol‐2‐yl]methanone 
• 1415829-38-7 N-[3-(3,4-dimethoxyphenyl)imidazo[1,2-a]pyrazine-8-yl]-4-methyl-benzenesulfonamide 
• 1415830-14-6 8-chloro-3-(3,4-dimethoxyphenyl)imidazo[1,2-a]pyrazine 
• 1415830-12-4 2-[(3-chloropyrazin-2-yl)amino]-1-(3,4-dimethoxyphenyl)ethanone 
• 1415830-09-9 2-[(3-chloropyrazin-2-yl)amino]-1-(3,4-dimethoxyphenyl)ethanol 
• 1415830-06-6 2-azido-1-(3,4-dimethoxyphenyl)ethanol 
• 6924-15-8 2-amino-1-(3,4-dimethoxy-phenyl)-ethanol 
• 109224-71-7 2-(aminomethyl)-2-(3,4-dimethoxyphenyl)-1,2-dioxolane 
• 947595-22-4 3β-(4-methylphenyl)tropane-2β-N-3,4-dimethoxyphenacylcarboxthioamide ethylene ketal 

Relevant articles and documents

New 2,9-disubstituted-1,10-phenanthroline derivatives with anticancer activity by selective targeting of telomeric G-quadruplex DNA

Fifteen new 1,10-phenanthrolines disubstituted at positions 2 and 9 via amide bonds with different heterocycles have been designed and synthesized as G-quadruplex DNA stabilizers. Ten compounds were evaluated for the in vitro anticancer activity against 60 human tumor cell lines panel, four of them showing a very good inhibitory activity on several cell lines. To assess the ability of the most active compounds to interact with G-quadruplex DNA (G4-DNA), circular dichroism experiments were performed. The potency of the compounds to stabilize the G4-DNA has been shown from the thermal denaturation experiments. The mechanism of compounds binding to DNA and to G4-DNA was theoretically investigated by molecular docking studies. The experimental results demonstrated excellent capacity of the two compounds bearing two pyridin-3-yl residues (methylated and non-methylated) to act as selective G-quadruplex binders with promising anticancer activity.

2- and 3-substituted imidazo[1,2-a]pyrazines as inhibitors of bacterial type IV secretion

A novel series of 8-amino imidazo[1,2-a]pyrazine derivatives has been developed as inhibitors of the VirB11 ATPase HP0525, a key component of the bacterial type IV secretion system. A flexible synthetic route to both 2- and 3-aryl substituted regioisomers has been developed. The resulting series of imidazo[1,2-a]pyrazines has been used to probe the structure-activity relationships of these inhibitors, which show potential as antibacterial agents.

SUBSTITUTED 8 - AMINO - IMIDAZO [1, 2-A] PYRAZ1NES AS ANTIBACTERIAL AGENTS

The present invention relates to substituted imidazo[1,2-a]pyrazines of Formula (I) and their use as antibacterial agents.