6924-15-8

Usage

Uses

Used in Pharmaceutical Industry:
2-AMINO-1-(3,4-DIMETHOXY-PHENYL)-ETHANOL is used as a psychoactive agent for its potential effects on the central nervous system. Its unique structure with a phenyl ring, methoxy groups, amino group, and hydroxyl group may contribute to its pharmacological activity.
Used in Organic Synthesis:
2-AMINO-1-(3,4-DIMETHOXY-PHENYL)-ETHANOL is used as a building block in the synthesis of other chemical compounds. Its versatile structure allows for various chemical reactions, making it a valuable intermediate in the production of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Research and Development:
2-AMINO-1-(3,4-DIMETHOXY-PHENYL)-ETHANOL is used as a research compound to further explore its potential uses and applications. Scientists and researchers are investigating its properties and interactions with biological systems to better understand its potential as a therapeutic agent or in other applications.

Upstream product

• 99076-44-5 (+/-)-3,4-Dimethoxy-mandelsaeure-amid 
• 6309-18-8 2-(3,4-dimethoxyphenyl)-2-hydroxyacetonitrile 
• 95392-01-1 2-(3,4-dimethoxyphenyl)-2-((trimethylsilyl)oxy)acetonitrile 
• 64-19-7 acetic acid 
• 64-17-5 ethanol 
• 46729-91-3 1-(3,4-dimethoxyphenyl)-2-nitroethan-1-one 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 1415830-06-6 2-azido-1-(3,4-dimethoxyphenyl)ethanol 
• 187101-52-6 2-azido-1-(3,4-dimethoxyphenyl)ethanone 
• 1835-02-5 2-Bromo-1-(3,4-dimethoxyphenyl)ethanone 
• 1131-62-0 1-(3,4-dimethoxyphenyl)ethanone 
• 39220-86-5 2-nitro-1-(3,4-dimethoxyphenyl)ethanol 
• 68413-92-3 sodium (3,4-dimethoxyphenyl)(hydroxy)methanesulfonate 
• 75-52-5 nitromethane 

Downstream Products

• 54837-88-6 piperonal-(β-hydroxy-3,4-dimethoxy-phenethylimine) 
• 3865-99-4 5-(3,4-dimethoxy-phenyl)-4,5-dihydro-oxazol-2-ylamine 
• 54837-87-5 [2-(3,4-Dimethoxy-phenyl)-2-hydroxy-ethyl]-carbamic acid ethyl ester 
• 87351-89-1 α-<<(2-nitrobenzyl)amino>methyl>-3,4-dimethoxybenzyl alcohol 
• 67387-93-3 5-(3,4-dimethoxyphenyl)-2-thiazolidinone 
• 1148108-66-0 4-chloro-N-[2-(3,4-dimethoxyphenyl)-2-hydroxyethyl]butyramide 
• 1415830-09-9 2-[(3-chloropyrazin-2-yl)amino]-1-(3,4-dimethoxyphenyl)ethanol 
• 1415830-12-4 2-[(3-chloropyrazin-2-yl)amino]-1-(3,4-dimethoxyphenyl)ethanone 
• 1415830-14-6 8-chloro-3-(3,4-dimethoxyphenyl)imidazo[1,2-a]pyrazine 
• 1415829-38-7 N-[3-(3,4-dimethoxyphenyl)imidazo[1,2-a]pyrazine-8-yl]-4-methyl-benzenesulfonamide 
• 1335093-50-9 1-(3-(2-fluoroethoxy)-4-methoxybenzyl)-6,7-dimethoxyisoquinoline 
• 1335093-67-8 1-(3-(2-fluoroethoxy)-4-methoxybenzyl)-6,7-dimethoxyisoquinoline oxalate 
• 67387-92-2 5-(3,4-dimethoxyphenyl)-2-oxazolidinethione 
• 5653-66-7 1-(3,4-dimethoxyphenyl)-2-(methylamino)ethan-1-ol 

Relevant academic research and scientific papers

Chiral-Organotin-Catalyzed Kinetic Resolution of Vicinal Amino Alcohols

A highly efficient kinetic resolution of racemic amino alcohols has been achieved for the first time with a chiral tin catalyst. A chiral organotin compound with 3,4,5-trifluorophenyl groups at the 3,3′-positions of the binaphthyl framework enabled this transformation with excellent yield and high enantioselectivity. The process tolerates aryl- and alkyl-substituted amino alcohols and a variety of other substrates, affording the corresponding products in high enantioselectivity and with s factors up to >500.

2- and 3-substituted imidazo[1,2-a]pyrazines as inhibitors of bacterial type IV secretion

A novel series of 8-amino imidazo[1,2-a]pyrazine derivatives has been developed as inhibitors of the VirB11 ATPase HP0525, a key component of the bacterial type IV secretion system. A flexible synthetic route to both 2- and 3-aryl substituted regioisomers has been developed. The resulting series of imidazo[1,2-a]pyrazines has been used to probe the structure-activity relationships of these inhibitors, which show potential as antibacterial agents.

SUBSTITUTED 8 - AMINO - IMIDAZO [1, 2-A] PYRAZ1NES AS ANTIBACTERIAL AGENTS

The present invention relates to substituted imidazo[1,2-a]pyrazines of Formula (I) and their use as antibacterial agents.

Synthesis of the isoquinoline alkaloid, crispine C

The first total synthesis of the isoquinoline alkaloid, crispine C is described in seven steps using a Henry reaction and the Pictet-Gams variant of the Bischler-Napieralski reaction to effect the key transformations.

First total synthesis of crispine B by nitro aldol and the Bischler-Napieralski reaction

A pyrrolo[2,1-a]isoquinoline alkaloid, crispine B, was firstly synthesized in 55% overall yield from 3,4-dimethoxyaldehyde via five steps by employing nitro-aldol reaction and the Bischler-Napieralski reaction.

Use of 2-phenylmorpholin-5-one derivatives

A 2-phenylmorpholin-5-one derivative having the formula (I): wherein R1 represents a C1 to C8 alkyl group, a C3 to C7 cycloalkyl group or an indanyl group, R2 represents a C1 to C4 alkyl group, R3 represents a hydrogen atom, a C1 to C5 alkyl group, etc., R4 represents a hydrogen atom, a C1 to C6 alkyl group, etc., R5, R6 represent a hydrogen atom, a C1 to C5 alkyl group, etc.,an optical isomer thereof or a pharmacologically acceptable salt thereof, or a hydrate or solvate thereof and a pharmaceutical composition containing the same.The above compound has a strong type IV phosphodiesterase (PDE) inhibitory activity and has bronchodilater and antiinflammatory effects.

Synthesis of 2-Aryl-2,3-dihydro-oxazolopyrrolopyridin-5-one and 2-Aryl-2,3-dihydro-oxazolopyrrolopyridin-5-one

A variety of 2-aryl-2,3-dihydro-oxazolopyrrolopyridin-5-one and 2-aryl-2,3-dihydro-oxazolopyrrolopyridin-5-one were prepared. The absolute configuration of the chiral centers were studied thoroughly from which the structural and stereoformulea of these compounds were deduced by using nmr and microanalysis technique.

Specific dopamine D-1 and DA1 properties of 4-(mono- and -dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline and its tetrahydrothieno[2,3-c]pyridine analogue

The title compounds were prepared and examined to elucidate further the structure-activity relationships of dopamine agonists related to nomifensine. Two of the compounds, 4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline and 4-(3,4-dihydroxyphenyl)-