18714-77-7Relevant academic research and scientific papers
3,3-Bis-2-phenylacrylaldehydes as Building Sets for Thiophenes and Pyrazoles
Rudorf, W.-D.
, p. 321 - 326 (2007/10/02)
Alkylation of the dithiolate 2 either with methyliodide and α-CH-acid halogenated compounds R2-CH2-X or only with the latter reagent yields ketene S,S-acetals 3.Base catalyzed cyclization of 3 leads to the thiophenes 4.Reaction of 3,3-bis-2-phenylacrylaldehyde 3f with hydrazine affords a mixture of aldehydrazone 5 and aldazine 6.The pyrazole 7a is obtained by refluxing 5 in 1-butanol.Mass spectra of the pyrazoles 7b,c and reaction of 3f with aniline prove the attack of a nucleophile on the formyl group in the first step.
