187155-32-4

Downstream Products

• 187155-33-5 (2S,3R,5R,6R)-6-[(R)-(tert-Butyl-dimethyl-silanyloxy)-phenyl-methyl]-3-formyl-3-methyl-4,4,7-trioxo-4λ⁶-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester 
• 187155-34-6 (2S,3R,5R,6R)-6-[(R)-(tert-Butyl-dimethyl-silanyloxy)-phenyl-methyl]-3-(methoxyimino-methyl)-3-methyl-4,4,7-trioxo-4λ⁶-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester 
• 187155-35-7 (2S,3R,5R,6R)-6-((R)-Hydroxy-phenyl-methyl)-3-(methoxyimino-methyl)-3-methyl-4,4,7-trioxo-4λ⁶-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester 

Relevant academic research and scientific papers

Studies on penam sulfones III. Synthesis and β-lactamase inhibitory activity of sodium (6R)-6-(α-hydroxybenzyl)-2β-methoxyiminomethyl-2α-methylpenam-3α -carboxylate 1,1-dioxide and sodium 2β-acyl-2α-methylpenam-3α-carboxylate 1,1-dioxide

The synthesis and in vitro synergies of (6R)-6-(α-hydroxybenzyl)-2β-methoxyiminomethyl-2α-methylpenam-3α -carboxylate 1,1-dioxide (4) and 2β-acyl-2α-methylpenam-3α-carboxylate 1,1-dioxide (15) are described. Compound 15 showed good in vitro synergy in combination with piperacillin and ceftazidime against chromosomally mediated class I cephalosporinase producing organisms including TEM, SHV, and OXA-type enzymes producing microorganisms.