Studies on penam sulfones III. Synthesis and β-lactamase inhibitory activity of sodium (6R)-6-(α-hydroxybenzyl)-2β-methoxyiminomethyl-2α-methylpenam-3α -carboxylate 1,1-dioxide and sodium 2β-acyl-2α-methylpenam-3α-carboxylate 1,1-dioxide

DOI: 10.1016/S0960-894X(96)00575-6

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 11 - 14 (1997)

Update date:2022-07-31

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Authors:

Czajkowski, David P.

Reddy, Andhe V.N.

Setti, Eduardo L.

Phillips, Oludotun A.

Micetich, Ronald G.

Kunugita, Chieko

Maiti, Samarendra N.

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Article abstract of DOI:10.1016/S0960-894X(96)00575-6

The synthesis and in vitro synergies of (6R)-6-(α-hydroxybenzyl)-2β-methoxyiminomethyl-2α-methylpenam-3α -carboxylate 1,1-dioxide (4) and 2β-acyl-2α-methylpenam-3α-carboxylate 1,1-dioxide (15) are described. Compound 15 showed good in vitro synergy in combination with piperacillin and ceftazidime against chromosomally mediated class I cephalosporinase producing organisms including TEM, SHV, and OXA-type enzymes producing microorganisms.

Full text of DOI:10.1016/S0960-894X(96)00575-6

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