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Studies on penam sulfones III. Synthesis and β-lactamase inhibitory activity of sodium (6R)-6-(α-hydroxybenzyl)-2β-methoxyiminomethyl-2α-methylpenam-3α -carboxylate 1,1-dioxide and sodium 2β-acyl-2α-methylpenam-3α-carboxylate 1,1-dioxide

DOI: 10.1016/S0960-894X(96)00575-6

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 11 - 14 (1997)

Update date:2022-07-31

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Authors:

Czajkowski, David P.Czajkowski, David P.

Reddy, Andhe V.N.Reddy, Andhe V.N.

Setti, Eduardo L.Setti, Eduardo L.

Phillips, Oludotun A.Phillips, Oludotun A.

Micetich, Ronald G.Micetich, Ronald G.

Kunugita, ChiekoKunugita, Chieko

Maiti, Samarendra N.Maiti, Samarendra N.

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Article abstract of DOI:10.1016/S0960-894X(96)00575-6

The synthesis and in vitro synergies of (6R)-6-(α-hydroxybenzyl)-2β-methoxyiminomethyl-2α-methylpenam-3α -carboxylate 1,1-dioxide (4) and 2β-acyl-2α-methylpenam-3α-carboxylate 1,1-dioxide (15) are described. Compound 15 showed good in vitro synergy in combination with piperacillin and ceftazidime against chromosomally mediated class I cephalosporinase producing organisms including TEM, SHV, and OXA-type enzymes producing microorganisms.

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Full text of DOI:10.1016/S0960-894X(96)00575-6

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Product name:(2S,3R,5R,6R)-6-[(R)-(tert-Butyl-dimethyl-silanyloxy)-phenyl-methyl]-3-hydroxymethyl-3-methyl-4,4,7-trioxo-4λ6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester

Cas No:187155-32-4

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