187217-99-8

Basic information

• Product Name: 1-(2,2,2-TRIFLUOROETHYL)PIPERIDIN-4-AMINE
• Synonyms: 1-(2,2,2-trifluoroethyl)piperidin-4-aMine.HCl;1-(2,2,2-Trifluoroethyl)-4-piperidinamine;1-(2,2,2-TRIFLUOROETHYL)PIPERIDIN-4-AMINE;AKOS BBV-015055;ART-CHEM-BB B038142
• CAS NO: 187217-99-8
• Molecular Formula: C₇H₁₃F₃N₂
• Molecular Weight: 182.19
• Mol File: 187217-99-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(2,2,2-TRIFLUOROETHYL)PIPERIDIN-4-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,2,2-TRIFLUOROETHYL)PIPERIDIN-4-AMINE(187217-99-8)
• EPA Substance Registry System: 1-(2,2,2-TRIFLUOROETHYL)PIPERIDIN-4-AMINE(187217-99-8)

Safety Data

• Hazard Codes: Xn,N
• Statements: 22-50
• Safety Statements: 61
• Hazardous Substances Data: 187217-99-8(Hazardous Substances Data)

Usage

Description

1-(2,2,2-TRIFLUOROETHYL)PIPERIDIN-4-AMINE is a chemical compound with the molecular formula C8H16F3N. It is a piperidine derivative with a trifluoroethyl substituent, making it a tertiary amine. 1-(2,2,2-TRIFLUOROETHYL)PIPERIDIN-4-AMINE is known for its unique structure and properties, which make it a versatile building block in the creation of diverse molecules. Its potential applications in medicinal chemistry and drug development are attributed to its ability to interact with biological systems.

Uses

Used in Pharmaceutical Industry:
1-(2,2,2-TRIFLUOROETHYL)PIPERIDIN-4-AMINE is used as an intermediate in the synthesis of pharmaceuticals and organic compounds. Its unique structure allows it to be a key component in the development of new drugs and therapeutic agents.
Used in Medicinal Chemistry:
1-(2,2,2-TRIFLUOROETHYL)PIPERIDIN-4-AMINE is used as a building block in medicinal chemistry for the creation of diverse molecules. Its ability to interact with biological systems makes it a promising candidate for the development of new pharmaceuticals and therapeutic agents.
Used in Organic Compounds Synthesis:
1-(2,2,2-TRIFLUOROETHYL)PIPERIDIN-4-AMINE is used as an intermediate in the synthesis of various organic compounds. Its versatility and unique properties make it a valuable component in the development of new organic molecules for various applications.

Upstream product

• 176910-36-4 2,2,2-trifluoro-1-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)ethan-1-one 
• 81363-14-6 1-(2,2,2-trifluoroethyl)piperidin-4-one oxime 
• 710350-66-6 8-(2,2,2-trifluoroethyl)-1,4-dioxa-8-azaspiro[4.5]-decane 
• 177-11-7 4,4-ethylenedioxy-piperidine 

Downstream Products

• 1033836-10-0 6-Phenyl-N-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)nicotinamide 
• 1033844-11-9 6-(2-fluorophenyl)-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]nicotinamide 
• 1033836-12-2 6-(3-Fluorophenyl)-N-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)nicotinamide 
• 1033844-09-5 6-(2,5-difluorophenyl)-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]nicotinamide 
• 1033844-50-6 6-(3-cyanophenyl)-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]nicotinamide 
• 1033844-51-7 6-(2-cyanophenyl)-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]nicotinamide 
• 1365083-95-9 4-(2,5-difluorobenzylidene)-N-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)piperidine-1-carboxamide 
• 1350438-52-6 C₂₃H₂₅F₃N₆O₄S₂ 

Relevant articles and documents

Lead Optimization toward Proof-of-Concept Tools for Huntington's Disease within a 4-(1 H -Pyrazol-4-yl)pyrimidine Class of Pan-JNK Inhibitors

Through medicinal chemistry lead optimization studies focused on calculated properties and guided by X-ray crystallography and computational modeling, potent pan-JNK inhibitors were identified that showed submicromolar activity in a cellular assay. Using in vitro ADME profiling data, 9t was identified as possessing favorable permeability and a low potential for efflux, but it was rapidly cleared in liver microsomal incubations. In a mouse pharmacokinetics study, compound 9t was brain-penetrant after oral dosing, but exposure was limited by high plasma clearance. Brain exposure at a level expected to support modulation of a pharmacodynamic marker in mouse was achieved when the compound was coadministered with the pan-cytochrome P450 inhibitor 1-aminobenzotriazole. (Chemical Presented)

Nicotinamide Derivatives

The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein the substituents are as defined herein, compositions containing such compounds and the uses of such compounds for the treatment o