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187217-99-8

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187217-99-8 Usage

Description

1-(2,2,2-TRIFLUOROETHYL)PIPERIDIN-4-AMINE is a chemical compound with the molecular formula C8H16F3N. It is a piperidine derivative with a trifluoroethyl substituent, making it a tertiary amine. 1-(2,2,2-TRIFLUOROETHYL)PIPERIDIN-4-AMINE is known for its unique structure and properties, which make it a versatile building block in the creation of diverse molecules. Its potential applications in medicinal chemistry and drug development are attributed to its ability to interact with biological systems.

Uses

Used in Pharmaceutical Industry:
1-(2,2,2-TRIFLUOROETHYL)PIPERIDIN-4-AMINE is used as an intermediate in the synthesis of pharmaceuticals and organic compounds. Its unique structure allows it to be a key component in the development of new drugs and therapeutic agents.
Used in Medicinal Chemistry:
1-(2,2,2-TRIFLUOROETHYL)PIPERIDIN-4-AMINE is used as a building block in medicinal chemistry for the creation of diverse molecules. Its ability to interact with biological systems makes it a promising candidate for the development of new pharmaceuticals and therapeutic agents.
Used in Organic Compounds Synthesis:
1-(2,2,2-TRIFLUOROETHYL)PIPERIDIN-4-AMINE is used as an intermediate in the synthesis of various organic compounds. Its versatility and unique properties make it a valuable component in the development of new organic molecules for various applications.

Check Digit Verification of cas no

The CAS Registry Mumber 187217-99-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,7,2,1 and 7 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 187217-99:
(8*1)+(7*8)+(6*7)+(5*2)+(4*1)+(3*7)+(2*9)+(1*9)=168
168 % 10 = 8
So 187217-99-8 is a valid CAS Registry Number.

187217-99-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(2,2,2-trifluoroethyl)piperidin-4-amine

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:187217-99-8 SDS

187217-99-8Relevant articles and documents

Lead Optimization toward Proof-of-Concept Tools for Huntington's Disease within a 4-(1 H -Pyrazol-4-yl)pyrimidine Class of Pan-JNK Inhibitors

Wityak, John,McGee, Kevin F.,Conlon, Michael P.,Song, Ren Hua,Duffy, Bryan C.,Clayton, Brent,Lynch, Michael,Wang, Gwen,Freeman, Emily,Haber, James,Kitchen, Douglas B.,Manning, David D.,Ismail, Jiffry,Khmelnitsky, Yuri,Michels, Peter,Webster, Jeff,Irigoyen, MacArena,Luche, Michele,Hultman, Monica,Bai, Mei,Kuok, Iokteng D.,Newell, Ryan,Lamers, Marieke,Leonard, Philip,Yates, Dawn,Matthews, Kim,Ongeri, Lynette,Clifton, Steve,Mead, Tania,Deupree, Susan,Wheelan, Pat,Lyons, Kathy,Wilson, Claire,Kiselyov, Alex,Toledo-Sherman, Leticia,Beconi, Maria,Mu?oz-Sanjuan, Ignacio,Bard, Jonathan,Dominguez, Celia

, p. 2967 - 2987 (2015/04/27)

Through medicinal chemistry lead optimization studies focused on calculated properties and guided by X-ray crystallography and computational modeling, potent pan-JNK inhibitors were identified that showed submicromolar activity in a cellular assay. Using in vitro ADME profiling data, 9t was identified as possessing favorable permeability and a low potential for efflux, but it was rapidly cleared in liver microsomal incubations. In a mouse pharmacokinetics study, compound 9t was brain-penetrant after oral dosing, but exposure was limited by high plasma clearance. Brain exposure at a level expected to support modulation of a pharmacodynamic marker in mouse was achieved when the compound was coadministered with the pan-cytochrome P450 inhibitor 1-aminobenzotriazole. (Chemical Presented)

Nicotinamide Derivatives

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Page/Page column 19-20, (2008/12/06)

The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein the substituents are as defined herein, compositions containing such compounds and the uses of such compounds for the treatment o

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