1033836-12-2

Basic information

• Product Name: 3-PYRIDINECARBOXAMIDE, 6-(3-FLUOROPHENYL)-N-[1-(2,2,2-TRIFLUOROETHYL)-4-PIPERIDINYL]-
• Synonyms: 3-PYRIDINECARBOXAMIDE, 6-(3-FLUOROPHENYL)-N-[1-(2,2,2-TRIFLUOROETHYL)-4-PIPERIDINYL]-;6-(3-fluorophenyl)-N-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)nicotinaMide;HPGDS inhibitor 1;6-(3-Fluorophenyl)-N-[1-(2,2,2-trifluoroethyl)-4-piperidinyl]-3-pyridinecarboxamide;HPGDS inhibitor 1, >=98%;Prostaglandin D Synthase (hematopoietic-type) Inhibitor I
• CAS NO: 1033836-12-2
• Molecular Formula: C₁₉H₁₉F₄N₃O
• Molecular Weight: 381.3672728
• Product Categories: Inhibitors
• Mol File: 1033836-12-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• Solubility: Soluble in DMSO
• CAS DataBase Reference: 3-PYRIDINECARBOXAMIDE, 6-(3-FLUOROPHENYL)-N-[1-(2,2,2-TRIFLUOROETHYL)-4-PIPERIDINYL]-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-PYRIDINECARBOXAMIDE, 6-(3-FLUOROPHENYL)-N-[1-(2,2,2-TRIFLUOROETHYL)-4-PIPERIDINYL]-(1033836-12-2)
• EPA Substance Registry System: 3-PYRIDINECARBOXAMIDE, 6-(3-FLUOROPHENYL)-N-[1-(2,2,2-TRIFLUOROETHYL)-4-PIPERIDINYL]-(1033836-12-2)

Safety Data

• Hazardous Substances Data: 1033836-12-2(Hazardous Substances Data)

Usage

Biological Activity

hpgds inhibitor 1 is an oral potent and selective inhibitor of hematopoietic prostaglandin d synthase (hpgds) with ic50 value of 0.7nm [1].prostaglandin d2 (pgd2) is a mediator of allergy and inflammation. it is isomerized from pgh2 by pgds. this production is important in airway allergic and inflammatory processes. hpgds inhibitor 1 has a 3-fluorine substituent, making it stable in the in vitro human microsome assay. it has potent effects in enzyme assay and cellular assay with ic50 values of 0.7nm and 32nm, respectively. in addition, the potency is equal against purified hpgds from various species with ic50 values ranging from 0.5-2.3nm. besides that, hpgds inhibitor 1 is selective against hpgds over other relevant human enzymes including l-pgds, mpges, cox-1, cox-2 and 5 lox [1].in a model of antigen-induced airway response in allergic sheep, treatment of hpgds inhibitor 1 completely prevents the late asthma reaction and blocks the airway hyper-responsiveness [1].

references

[1] carron c p, trujillo j i, olson k l, et al. discovery of an oral potent selective inhibitor of hematopoietic prostaglandin d synthase (hpgds). acs medicinal chemistry letters, 2010, 1(2): 59-63.

Upstream product

• 187217-99-8 1-(2,2,2-trifluoroethyl)piperidin-4-ylamine 
• 582325-22-2 6-(3-fluorophenyl)-3-pyridinecarboxylic acid 

Relevant articles and documents

Nicotinamide Derivatives

The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein the substituents are as defined herein, compositions containing such compounds and the uses of such compounds for the treatment o