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Usage

Uses

Used in Organic Synthesis:
(5S)-5-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)dihydrofuran-2(3H)-one is used as an intermediate in organic synthesis for the development of novel compounds with potential applications in various industries. Its unique structure allows for further functionalization and modification, making it a valuable building block for the creation of new molecules.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (5S)-5-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)dihydrofuran-2(3H)-one is used as a key component in the design and synthesis of new pharmaceuticals. Its structural features may contribute to the development of drugs with improved efficacy, selectivity, and reduced side effects.
Used in Pharmaceutical Industry:
(5S)-5-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)dihydrofuran-2(3H)-one is used as an active pharmaceutical ingredient (API) for the development of new drugs targeting various medical conditions. Its unique properties and reactivity may lead to the discovery of innovative therapeutic agents with improved pharmacological profiles.
Used in Biochemical Research:
In the realm of biochemistry, (5S)-5-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)dihydrofuran-2(3H)-one is used as a research tool to study the interactions between biological molecules and potential drug candidates. Its unique structure may provide insights into the mechanisms of action of various biological processes and contribute to the understanding of complex molecular interactions.

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 32780-06-6 (5S)-5-(hydroxymethyl)-2-oxo-tetrahydrofuran 

Downstream Products

• 1221442-84-7 N-(4-(7-(((5R)-4-oxaspiro[2.4]heptane-5-yl)methoxy)quinolin-4-yloxy)-3-fluorophenyl)-2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazole-4-carboxamide 
• 1221443-03-3 N'-(4-(7-(((5R)-4-oxaspiro[2.4]heptane-5-yl)methoxy)quinolin-4-yloxy)-3-fluorophenyl)-N-phenylcyclopropane-1,1-dicarboxamide 
• 36326-34-8 (S)-(5,5-dimethyltetrahydrofuran-2-yl)methanol 
• 133328-94-6 (4S,5S)-5-Benzyloxy-4-propyl-tetrahydro-pyran-2-one 
• 133328-93-5 (4R,5S)-5-Benzyloxy-4-propyl-tetrahydro-pyran-2-one 
• 133328-95-7 (4S,5S)-5-Benzyloxy-4-methyl-tetrahydro-pyran-2-one 
• 133328-95-7 (4R,5S)-5-Benzyloxy-4-methyl-tetrahydro-pyran-2-one 
• 133328-96-8 (4R,5S)-5-Benzyloxy-4-butyl-tetrahydro-pyran-2-one 
• 133328-91-3 (S)-5-Benzyloxy-tetrahydro-pyran-2-one 
• 119770-85-3 (S)-5-Benzyloxy-5,6-dihydro-pyran-2-one 
• 334947-47-6 (2S,5E)-7-acetoxy-1-tert-butyldiphenylsiloxy-5-hepten-1-ol 

Relevant academic research and scientific papers

Ring-opened 4-hydroxy-δ-valerolactone subunit as a key structural fragment of polyesters that degrade without acid formation

Random copolymers of ?-caprolactone with O-benzyl-protected 4-hydroxy- or 2,4-dihydroxy-δ-valerolactone after hydrogenation form γ-hydroxy functionalized polyesters that degrade via the cyclization to γ-butyrolactone fragments without carboxylic acid formation.

PYRAZOLE AMIDE DERIVATIVE

The present invention relates to a novel compound having a function of inhibiting RORγ activity. The present invention also relates to pharmaceutical composition comprising the compound, a use of the compound in treating or preventing autoimmune diseases, inflammatory diseases, metabolic diseases, or cancer diseases.

NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS

Disclosed herein are cannabinoid receptor ligands of formula (I) wherein A1, A5, Rx, X4, and z are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

COMPOUNDS AND METHODS OF USE

The present invention provides novel compounds useful in modulating the protein tyrosine kinase activity, and in modulating inter- and/or intra-cellular signaling. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

Synthesis of 2,5-disubstituted tetrahydrofurans catalyzed by palladium(0)

A stereoselective cyclization of an allylic ester to 2,5-disubstituted tetrahydrofurans catalyzed by palladium(0) is demonstrated. In this cyclization, acetoxy heptenol (6a) having a free hydroxy group prefered trans isomer to cis isomer. By the use of the protected acetoxy heptenol (6b), the cis selectivity was observed. The stereoselectivity was enhanced by the use of DPPIO ligand.

Conjugate addition to chiral γ-heterosubstituted δ-lactones as pivotal synthons from L-glutamic acid. Synthesis of an optically active lignan lactone; (-)-hinokinin

Asymmetric induction in conjugate addition of new chiral γ-heterosubstituted-α, β-unsaturated δ-lactones from L-glutamic acid was accomplished in high diastereoselectivity with the formation of trans-(R,S)-adducts and was disclosed to serve as a versatile procedure for the asymmetric synthesis of antileukemic lignan lactones.