18732-72-4Relevant academic research and scientific papers
A facile synthesis of 2,4-disubstituted thiazoles using MnO2
Yu, Yan-Bo,Chen, Hong-Liang,Wang, Li-Yi,Chen, Xin-Zheng,Fu, Bin
scheme or table, p. 4858 - 4865 (2010/04/05)
Structurally diverse thiazoles with electron-donating and electron-withdrawing groups were conveniently synthesized through manganese dioxide (MnO2) oxidation of the corresponding thiazolines. The effect of substitution at the 2- and 4-positions was investigated. The desired thiazoles with aryl or vinyl substitutions at the 2- or 4-position can be obtained in good to excellent yields.
