187336-24-9Relevant academic research and scientific papers
A practical synthesis of a hydroxylated sesquiterpene coumarin 10′R-acetoxy-11′-hydroxyumbelliprenin by regioselective dihydroxylation
Hattori, Yasunao,Kinami, Genki,Teruya, Kenta,Nosaka, Kazuto,Kobayashi, Kazuya,Akaji, Kenichi
, p. 423 - 428 (2013)
A practical synthesis of 10′R-acetoxy-11′-hydroxyumbelliprenin was achieved using regioselective Sharpless asymmetric dihydroxylation as a key reaction, in which the regioselectivity was achieved by using (DHQD) 2AQN as a ligand instead of the conventional (DHQD)2PHAL. 10′R-Acetoxy-11′-hydroxyumbelliprenin was synthesized by the coupling of a coumarin unit (umbelliferone) and sesquiterpene unit in 11% overall yield through 5 steps.
