187397-59-7

Upstream product

• 4128-17-0 (2E,6E)-farnesyl acetate 
• 187336-25-0 (10R)-10,11-isopropylidenedioxy-10,11-dihydrofarnesyl bromide 
• 187336-24-9 (2E,6E,4'R)-(2',2',5'-trimethyl-1',3'-oxolan-4'-yl)-3,7-dimethylnona-2,6-dien-1-ol 
• 111-02-4 2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene 
• 158578-42-8 (16R)-(4E,8E,12E)-17-Hydroxyl-16-(mesyloxy)-4,9,13,17-tetramethyl-4,8,12-octadecatrienyl acetate 
• 158578-38-2 (4E,8E,12E)-4,9,13,17-Tetramethyl-4,8,12,16-octadecatetraenyl acetate 
• 56882-10-1 (4E,8E,12E)-4,9,13,17-tetramethyl-4,8,12,16-octadecatetraen-1-ol 
• 158578-43-9 (3S)-(6E,10E,14E,18Z,22E)-2,3-Epoxy-2,6,10,15,23-pentamethyl-19-(methoxycarbonyl)-6,10,14,18,22-docosapentaene 
• 158648-71-6 (3S)-(6E,10E,14E,18Z)-2,3-Epoxy-2,6,10,15,23-pentamethyl-19-(hydroxymethyl)-6,10,14,18,22-tetracosapentaene 
• 158648-68-1 (20S)-(4E,8E,12E,16E)-20,21-Epoxy-4,8,13,17,21-pentamethyl-4,8,12,16-docosatetraen-1-al 
• 158648-70-5 (20S)-(4E,8E,12E,16E)-20,21-Epoxy-4,8,13,17,21-pentamethyl-4,8,12,16-docosatetraen-1-ol 
• 137372-85-1 2-[Bis-(2,2,2-trifluoro-ethoxy)-phosphoryl]-6-methyl-hept-5-enoic acid methyl ester 
• 130790-62-4 (R,2E,6E)-10,11-dihydroxy-3,7,11-trimethyldodeca-2,6-dienyl acetate 
• 130790-63-5 (2E,6E)-3,7-dimethyl-9-((R)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl)nona-2,6-dienyl acetate 

Relevant academic research and scientific papers

Potency and inactivation rates of analogues of an irreversible inhibitor of vertebrate oxidosqualene cyclase

Truncated, 22(23)-dihydro, and fluorinated analogues of (3S)-29-methylidene-2,3-oxidosqualene (29-MOS) were prepared and inhibitory potencies and rates of inactivation of rat oxidosqualene cyclase were measured. Rapid mechanism-based enzyme inactivation was observed for both methylidene and difluoromethylidene analogues with complete pro-side chains, but not for truncated analogues.