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18735-82-5

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18735-82-5 Usage

General Description

7-Bromo-4-hydroxy-2H-chromen-2-one, also known as 7-bromo-4-coumarinol, is a chemical compound with the molecular formula C9H5BrO3. It is a derivative of coumarin, a natural substance found in many plants and used in the production of various pharmaceuticals and fragrances. 7-Bromo-4-hydroxy-2H-chromen-2-one has been studied for its potential biological activities, including its antioxidant and anti-inflammatory properties. It is also under investigation for its potential as a drug candidate for the treatment of various diseases. 7-Bromo-4-hydroxy-2H-chromen-2-one has the potential for further research and development in the pharmaceutical and medical fields.

Check Digit Verification of cas no

The CAS Registry Mumber 18735-82-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,7,3 and 5 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 18735-82:
(7*1)+(6*8)+(5*7)+(4*3)+(3*5)+(2*8)+(1*2)=135
135 % 10 = 5
So 18735-82-5 is a valid CAS Registry Number.

18735-82-5 Well-known Company Product Price

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  • Aldrich

  • (732990)  7-Bromo-4-hydroxycoumarin  

  • 18735-82-5

  • 732990-250MG

  • 1,506.96CNY

  • Detail

18735-82-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 7-bromo-4-hydroxychromen-2-one

1.2 Other means of identification

Product number -
Other names 4-hydroxy-6-bromocoumarin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:18735-82-5 SDS

18735-82-5Relevant articles and documents

Novel conjugates of podophyllotoxin and coumarin: Synthesis, cytotoxicities, cell cycle arrest, binding CT DNA and inhibition of Topo IIβ

Hao, Shu-Yi,Feng, Shi-Liang,Wang, Xing-Rong,Wang, Zhichao,Chen, Shi-Wu,Hui, Ling

supporting information, p. 2129 - 2135 (2019/07/05)

A series of conjugates of podophyllotoxin and coumarin were prepared using the click reaction, and their cytotoxicities against A549, HepG2, HeLa, and LoVo cells were evaluated. Among them, compound 14e exhibited the strongest cytotoxicities against these cancer cells with IC50 values of 4.9–17.5 μM. Furthermore, 14e disrupted microtubules and induced cell cycle arrest at G1 phase by regulating P21 and Cyclin D1 in LoVo cells. In addition, 14e bond CT DNA and selectively inhibited Topo IIβ over Topo IIα. Molecular docking model showed that 14e appeared to form stable hydrogen bonds with several DNA bases and residue Gln778. Taken together, these conjugates have the potential to be developed as anti-tumor drugs.

BENZOISOXAZOLE-SUBSTITUTED COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION

-

Page/Page column 88, (2016/08/10)

Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.

Mapping the ATP-binding domain of DNA-dependent protein kinase (DNA-PK) with coumarin- and isocoumarin-derived inhibitors

Payne, Sara L.,Rodriguez-Aristegui, Sonsoles,Bardos, Julia,Cano, Celine,Golding, Bernard T.,Hardcastle, Ian R.,Peacock, Marcus,Parveen, Nahida,Griffin, Roger J.

scheme or table, p. 3649 - 3653 (2010/09/17)

Replacement of the core heterocycle of a defined series of chromen-4-one DNA-PK inhibitors by the isomeric chromen-2-one (coumarin) and isochromen-1-one (isocoumarin) scaffolds was investigated. Structure-activity relationships for DNA-PK inhibition were broadly consistent, albeit with a reduction of potency compared with the parent chromenone.

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