651780-07-3Relevant academic research and scientific papers
Coumarin NEDD8 activating enzyme inhibitor as well as preparation method and application thereof
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Paragraph 0102; 0106;; 0107, (2016/10/09)
The invention discloses a coumarin NEDD8 activating enzyme inhibitor in the general formula I as well as pharmaceutically acceptable salts, solvate, polymorphic substances, tautomers, metabolites and prodrugs of the coumarin NEDD8 activating enzyme inhibitor. The invention further discloses an application of the coumarin NEDD8 activating enzyme inhibitor to preparation of anti-tumor drugs and a preparation method of the coumarin NEDD8 activating enzyme inhibitor. Pharmacological results show that the compound has a good effect of resisting tumor cell proliferation and is clinically applicable to preparation of drugs for treating tumors.
FUSED HETEROARYL DERIVATIVES FOR USE AS P38 KINASE INHIBITORS IN THE TREATMENT OF I.A. RHEUMATOID ARTHRISTIS
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Page/Page column 40, (2010/11/30)
Compounds of formula (I): wherein A is a 5-membered heteroaryl ring are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38, such as rheumatoid arthritis.
