18740-35-7Relevant academic research and scientific papers
N-Nitrosated N-hydroxyguanidines are nitric oxide-releasing diazeniumdiolates
Southan, Garry J.,Srinivasan, Aloka,George, Clifford,Fales, Henry M.,Keefer, Larry K.
, p. 1191 - 1192 (1998)
N-Hydroxyguanidines can be nitrosatively converted to zwitterionic diazeniumdiolates of crystallographically-confirmed structure H2N+=C[NHR][N(O)NO]-, whose hydrolytic dissociation at physiological pH leads to both NO and N2O; the results appear to account for the formation of the 'potential intercellular nitric oxide carrier' produced on exposing NG- hydroxy-L-arginine (a metabolic intermediate in mammalian NO biosynthesis) to aerobic NO.
