7409-30-5Relevant articles and documents
A novel three-component reaction toward dihydrooxazolopyridines
Scheffelaar, Rachel,Paravidino, Monica,Muilwijk, Daan,Lutz, Martin,Spek, Anthony L.,De Kanter, Frans J. J.,Orru, Romano V. A.,Ruijter, Eelco
, p. 125 - 128 (2009)
Isocyano dihydropyridones accessible via a recently reported multicomponent reaction react with aldehydes and amines to afford dihydrooxazolopyridines in high yield. The scope and limitations of this novel multicomponent reaction were investigated. The ef
Zirconium-hydride-catalyzed site-selective hydroboration of amides for the synthesis of amines: Mechanism, scope, and application
Han, Bo,Jiao, Haijun,Wu, Lipeng,Zhang, Jiong
, p. 2059 - 2067 (2021/09/02)
Developing mild and efficient catalytic methods for the selective synthesis of amines is a longstanding research objective. In this respect, catalytic deoxygenative amide reduction has proven to be promising but challenging, as this approach necessitates selective C–O bond cleavage. Herein, we report the selective hydroboration of primary, secondary, and tertiary amides at room temperature catalyzed by an earth-abundant-metal catalyst, Zr-H, for accessing diverse amines. Various readily reducible functional groups, such as esters, alkynes, and alkenes, were well tolerated. Furthermore, the methodology was extended to the synthesis of bio- and drug-derived amines. Detailed mechanistic studies revealed a reaction pathway entailing aldehyde and amido complex formation via an unusual C–N bond cleavage-reformation process, followed by C–O bond cleavage.
Locking the Dynamic Axial Chirality of Biphenyl Crown Ethers through Threading
Kimura, Tomoya,Miyagawa, Shinobu,Takaya, Hikaru,Naito, Masaya,Tokunaga, Yuji
supporting information, p. 3897 - 3903 (2020/10/28)
This paper describes the syntheses of [2]rotaxanes comprising 23- and 26-membered biphenyl crown ethers as the macrocyclic components and secondary ammonium ions as the dumbbell-shaped components, and the locking of the dynamic axial chirality of the biph