187403-13-0

Upstream product

• 358-23-6 trifluoromethylsulfonic anhydride 
• 174603-02-2 benzyl (R)-2-cyclohexyl-2-hydroxyacetate 
• 100-39-0 benzyl bromide 
• 14328-52-0 (R)-2-amino-2-cyclohexyl acetic acid 
• 53585-93-6 (R)-(-)-hexahydromandelic acid 

Downstream Products

• 866890-31-5 methyl {4,6-O-benzylidene-3-O-[(S)-(benzyloxycarbonyl)(cyclohexyl)methyl]-β-D-galactopyranosyl}-(1->3)-2-azido-4,6-O-benzylidene-2-deoxy-β-D-galactopyranoside 
• 866890-41-7 methyl {2,4,6-tri-O-acetyl-3-O-[(S)-(benzyloxycarbonyl)(cyclohexyl)methyl]-β-D-galactopyranosyl}-(1->3)-2-(acetylamino)-4,6-di-O-acetyl-2-deoxy-β-D-galactopyranoside 
• 866890-36-0 methyl {2-O-acetyl-4,6-O-benzylidene-3-O-[(S)-1-(benzyloxycarbonyl)(cyclohexyl)methyl]-β-D-galactopyranosyl}-(1->3)-2-(acetylamino)-4,6-O-benzylidene-2-deoxy-β-D-galactopyranoside 
• 501937-21-9 (S)-Cyclohexyl-{(3S,4S)-3-[4-hydroxy-4-(3-phenyl-propyl)-piperidin-1-ylmethyl]-4-phenyl-pyrrolidin-1-yl}-acetic acid benzyl ester 
• 301182-22-9 (S)-Cyclohexyl-{(3S,4S)-3-[4-hydroxy-4-(3-phenyl-propyl)-piperidin-1-ylmethyl]-4-phenyl-pyrrolidin-1-yl}-acetic acid 

Relevant academic research and scientific papers

Selective Monovalent Galectin-8 Ligands Based on 3-Lactoylgalactoside

Galectin-8 has gained attention as a potential new pharmacological target for the treatment of various diseases, including cancer, inflammation, and disorders associated with bone mass reduction. To that end, new molecular probes are needed in order to better understand its role and its functions. Herein we aimed to improve the affinity and target selectivity of a recently published galectin-8 ligand, 3-O-[1-carboxyethyl]-β-d-galactopyranoside, by introducing modifications at positions 1 and 3 of the galactose. Affinity data measured by fluorescence polarization show that the most potent compound reached a KD of 12 μM. Furthermore, reasonable selectivity versus other galectins was achieved, making the highlighted compound a promising lead for the development of new selective and potent ligands for galectin-8 as molecular probes to examine the protein's role in cell-based and in vivo studies.

Synthesis of ganglioside mimics for binding studies with myelin-associated glycoprotein (MAG)

Glycosylation of 3-O-unprotected 2-azido-2-deoxy-galactopyranoside (compound 5) with O-(2,3-di-O-acyl-4,6-O-benzylidene-D-galactopyranosyl) trichloroacetimidates (compounds 4A, B) as glycosyl donors afforded β(1-3)-linked disaccharides (9A, B) in high yie