187404-33-7Relevant academic research and scientific papers
The first enantioselective synthesis of optically pure (R)- and (S)- 5,5''-dihydroxy-4',4''',7,7''-tetramethoxy-8,8''- biflavone and the reconfirmation of their absolute configuration
Lin, Guo-Qiang,Zhong, Min
, p. 1087 - 1090 (1997)
The first enantioselective synthesis of the optically pure (R)- and (S)-5,5''-dihydroxy-4',4''',7,7''-tetramethoxy-8,8''- biflavone is described. The key steps involve the intramolecular oxidative coupling of the cyanocuprate intermediate and Friedel-Crafts rearrangement. Their absolute configuration was reconfirmed by CD spectra.
