The first enantioselective synthesis of optically pure (R)- and (S)- 5,5''-dihydroxy-4',4''',7,7''-tetramethoxy-8,8''- biflavone and the reconfirmation of their absolute configuration

DOI: 10.1016/S0040-4039(96)02475-6

Source and publish data:

Tetrahedron Letters p. 1087 - 1090 (1997)

Update date:2022-08-03

Topics:

Authors:

Lin, Guo-Qiang

Zhong, Min

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Article abstract of DOI:10.1016/S0040-4039(96)02475-6

The first enantioselective synthesis of the optically pure (R)- and (S)-5,5''-dihydroxy-4',4''',7,7''-tetramethoxy-8,8''- biflavone is described. The key steps involve the intramolecular oxidative coupling of the cyanocuprate intermediate and Friedel-Crafts rearrangement. Their absolute configuration was reconfirmed by CD spectra.

Full text of DOI:10.1016/S0040-4039(96)02475-6

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