
Tetrahedron Letters p. 1087 - 1090 (1997)
Update date:2022-08-03
Topics:
Lin, Guo-Qiang
Zhong, Min
The first enantioselective synthesis of the optically pure (R)- and (S)-5,5''-dihydroxy-4',4''',7,7''-tetramethoxy-8,8''- biflavone is described. The key steps involve the intramolecular oxidative coupling of the cyanocuprate intermediate and Friedel-Crafts rearrangement. Their absolute configuration was reconfirmed by CD spectra.
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