18741-42-9

Upstream product

• 2131-55-7 4-Chlorophenyl isothiocyanate 
• 5326-47-6 2-amino-5-iodobenzoic acid 

Downstream Products

• 105362-82-1 3-Amino-2-(4-chloro-phenylamino)-6-iodo-3H-quinazolin-4-one 
• 37498-09-2 2-benzylsulfanyl-3-(4-chloro-phenyl)-6-iodo-3H-quinazolin-4-one 
• 1025831-55-3 N-(2-hydroxyethyl)-2-[(3-(4-chlorophenyl)-4-oxo-6-iodo-3H-quinazolin-2-yl)thio]acetamideO 
• 958867-60-2 N-ethoxymethine-N'-[2(3-(4-chlorophenyl)-4-oxo-6-iodo-3H-quinazolin-2-yl)thioacetyl]hydrazine 
• 958867-61-3 N-formyl-N'-[2-(3-(4-chlorophenyl)-4-oxo-6-iodo-3H-quinazolin-2-yl)-thioacetyl]-hydrazine 

Relevant academic research and scientific papers

Eco-friendly rapid synthesis of 3-substituted-2-thioxo-2,3-dihydroquinazolin-4(1H)-ones in choline chloride based deep eutectic solvent

A series of 3-substituted-2-thioxo-2,3-dihydroquinazolin-4(1H)-ones and 6-iodo-3-substituted-2-thioxo-2,3-dihydroquinazolin-4(1H)-ones were synthesized in choline chloride/urea deep eutectic solvent. Substituted 2-mercapto-4(3H)-quinazolinones were synthesized from anthranilic acid or 5-iodoanthranilic acid and appropriate isothiocyanates in good to excellent yields. Isolation of final product was easy and required no further purification. Synthesis of these compounds was rapid, selective, and catalyst free, while preparation of deep eutectic solvent was easy, components are readily available, cheap, and environmentally friendly.

Synthesis of some new substituted 2-mercaptoquinazoline analogs as potential antimicrobial agents

A new series of substituted 2-mercapto-3-(4-chlorophenyl)-6-iodo-3H- quinazolin-4-ones was prepared and screened for antimicrobial activity. Compounds 11, 13, 17, and 18 showed a remarkably broad spectrum of antimicrobial activity and could be useful as t