187454-83-7

Basic information

• Product Name: 8-isopropyl-4-oxo-1,4-dihydro-quinoline-2-carboxylic acid methyl ester
• CAS NO: 187454-83-7
• Molecular Weight: 245.278
• Mol File: 187454-83-7.mol

Chemical Properties

• CAS DataBase Reference: 8-isopropyl-4-oxo-1,4-dihydro-quinoline-2-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 8-isopropyl-4-oxo-1,4-dihydro-quinoline-2-carboxylic acid methyl ester(187454-83-7)
• EPA Substance Registry System: 8-isopropyl-4-oxo-1,4-dihydro-quinoline-2-carboxylic acid methyl ester(187454-83-7)

Safety Data

• Hazardous Substances Data: 187454-83-7(Hazardous Substances Data)

Upstream product

• 762-42-5 dimethyl acetylenedicarboxylate 
• 643-28-7 2-isopropylaniline 

Downstream Products

• 351419-77-7 4-[4-(8-isopropyl-4-phenyl-quinolin-2-yl)-4-oxo-butyryl]-benzoic acid methyl ester 
• 187400-85-7 ER-50891 
• 351419-76-6 4-[4-(4-ethyl-8-isopropyl-quinolin-2-yl)-4-oxo-butyryl]-benzoic acid methyl ester 
• 351419-82-4 4-[5-(8-isopropyl-4-phenyl-quinolin-2-yl)-1H-pyrrol-2-yl]-benzoic acid methyl ester 
• 351419-74-4 4-[4-(4-chloro-8-isopropyl-quinolin-2-yl)-4-oxo-butyryl]-benzoic acid methyl ester 
• 187402-75-1 4-[4-(8-isopropyl-4-methoxy-quinolin-2-yl)-4-oxo-butyryl]-benzoic acid methyl ester 
• 351419-81-3 4-[5-(4-ethyl-8-isopropyl-quinolin-2-yl)-1H-pyrrol-2-yl]-benzoic acid methyl ester 
• 351419-75-5 4-[4-(8-isopropyl-4-methyl-quinolin-2-yl)-4-oxo-butyryl]-benzoic acid methyl ester 
• 351419-79-9 4-[5-(8-isopropyl-4-methoxy-quinolin-2-yl)-1H-pyrrol-2-yl]-benzoic acid methyl ester 
• 351419-80-2 4-[5-(8-isopropyl-4-methyl-quinolin-2-yl)-1H-pyrrol-2-yl]-benzoic acid methyl ester 
• 351419-78-8 4-[5-(4-chloro-8-isopropyl-quinolin-2-yl)-1H-pyrrol-2-yl]-benzoic acid methyl ester 
• 351419-73-3 8-isopropyl-4-phenyl-quinoline-2-carboxylic acid methyl ester 
• 187401-59-8 8-isopropyl-4-phenyl-quinoline-2-carbaldehyde 

Relevant articles and documents

Syntheses and evaluation of quinoline derivatives as novel retinoic acid receptor α antagonists

In the course of studies on novel retinoids, we have designed and synthesized a series of quinoline derivatives. One of them, 4-[5-[8-(1-methylethyl)-4-phenyl-2-quinolinyl]-1H-2-pyrrolyl]benzoic acid (12f) shows potent RARα-selective antagonistic activity.

A mild and efficient synthesis of 4-quinolones and quinolone heterocycles

(Chemical Equation Presented) The cycloacylation of aniline derivatives to 4-quinolones in the presence of Eaton's reagent is described. This high-yielding methodology is applicable to a wide variety of functionalized anilines and requires milder conditio