187458-07-7

Basic information

• Product Name: 5-({[tert-butyl(dimethyl)silyl]oxy}methyl)tetrahydrofuran-2-yl acetate
• Synonyms: 5-({[tert-butyl(dimethyl)silyl]oxy}methyl)tetrahydrofuran-2-yl acetate
• CAS NO: 187458-07-7
• Molecular Weight: 274.433
• Mol File: 187458-07-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-({[tert-butyl(dimethyl)silyl]oxy}methyl)tetrahydrofuran-2-yl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 5-({[tert-butyl(dimethyl)silyl]oxy}methyl)tetrahydrofuran-2-yl acetate(187458-07-7)
• EPA Substance Registry System: 5-({[tert-butyl(dimethyl)silyl]oxy}methyl)tetrahydrofuran-2-yl acetate(187458-07-7)

Safety Data

• Hazardous Substances Data: 187458-07-7(Hazardous Substances Data)

Upstream product

• 32780-06-6 (5S)-5-(hydroxymethyl)-2-oxo-tetrahydrofuran 

Downstream Products

• 292638-85-8 acrylic acid methyl ester 
• 5983-09-5 2',3'-Dideoxyuridine 
• 121154-54-9 2',3'-dideoxy-α-D-uridine 
• 15379-30-3 2',3'-dideoxy-α-D-5-fluorouridine 
• 127592-40-9 2',3'-dideoxy-β-D-5-chlorouridine 
• 107036-62-4 5-fluoro-2',3'-dideoxycytidine 
• 3416-05-5 3'-Deoxythymidine 
• 107550-76-5 9-(2,3-dideoxy-β-D-ribofuranosyl)-6-(methylthio)purine 
• 107036-52-2 2',3'-dideoxy-β-D-5-azacytidine 
• 221459-13-8 tert-butyl<<(S)-2,3-dihydro-4-(phenylseleno)-2-furyl>methoxy>dimethylsilane 
• 221459-12-7 tert-butyl<<(S)-2,3-dihydro-4-(phenylthio)-2-furyl>methoxy>dimethylsilane 

Relevant articles and documents

NMR studies of pyrimidinic nucleosides derived from 2,3-dideoxy-d-ribose with inhibitory activity on LINE-1 mobility

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Synthesis of the Dideoxynucleosides ddC and CNT from Glutamic Acid, Ribonolactone, and Pyrimidine Bases

2,3-Dideoxyribose in suitably protected form was prepared from glutamic acid and coupled with silylated cytosine to give a mixture of the α-and β-anomers of 2',3'-dideoxycitidine.The anomer ratio depended on the Lewis acid used in the coupling, with EtAlCl2 favoring the β-anomer ddC, a potent anti-HIV drug.Conjugate addition of cyanide to a 4-butenolide prepared from D-ribonolactone gave a mixture of (racemic) α- and β-3-cyanobutyrolactones.Both isomers were reduced to lactols and coupled with thymine to give α/β-anomer pairs.The α-cyano lactone, the struct ure of which was established by X-ray crystallography, afforded an authentic sample of the putative (but in fact inactive) anti-HIV substance known in AIDS research as CNT.