1875153-79-9

Basic information

• Product Name: Adefovir iMpurity
• Synonyms: Adefovir iMpurity;Adefovir Dipivoxil Impurity 9;Adefovir Dipivoxil Impurity 17
• CAS NO: 1875153-79-9
• Molecular Formula: C15H24N5O6P
• Molecular Weight: 401.36
• Mol File: 1875153-79-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 578.3±60.0 °C(Predicted)
• Appearance: /
• Density: 1.42±0.1 g/cm3(Predicted)
• PKA: 4.17±0.10(Predicted)
• CAS DataBase Reference: Adefovir iMpurity(CAS DataBase Reference)
• NIST Chemistry Reference: Adefovir iMpurity(1875153-79-9)
• EPA Substance Registry System: Adefovir iMpurity(1875153-79-9)

Safety Data

• Hazardous Substances Data: 1875153-79-9(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 142341-05-7 9-<2-(phosphonomethoxy)ethyl>adenine, mono(pivaloyloxy)methyl ester 

Relevant articles and documents

Preparation method of adefovir dipivoxil impurities

The invention relates to a brand-new synthetic method of three adefovir dipivoxil impurities. The synthetic method is of great significance for synthesis of high-quality adefovir dipivoxil. The invention mainly studies synthesis of adefovir dipivoxil methyl ester impurity [[2-(6-amino-9H-purine-9-yl)-ethoxy]methyl]phosphonic acid (pivaloyloxymethyl)(methyl)ester (III), adefovir dipivoxil ethyl ester impurity [[2-(6-amino-9H-purine-9-yl)-ethoxy]methyl]phosphonic acid (pivaloyloxymethyl)(ethyl)ester (IV), adefovir dipivoxil amide impurity [[2-(6-pivaloylamido-9H-purine-9-yl)-ethoxy]methyl]phosphonic acid bi(pivaloyloxymethyl)ester (V). The specific synthetic route of the impurities is as shown in the specification.