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(+/-)-Pseudoyohimbon, also known as 17-oxoyohimban-16-carboxylic acid, is a naturally occurring indole alkaloid found in the bark of the West African tree, Pausinystalia yohimbe. It is an enantiomer mixture, meaning it consists of both the (+) and (-) forms of the compound. Pseudoyohimbon has been studied for its potential pharmacological properties, including its ability to act as an alpha-2 adrenergic receptor antagonist, which may contribute to its use in traditional medicine for treating conditions such as erectile dysfunction and anxiety. However, it is important to note that the safety and efficacy of pseudoyohimbon have not been fully established, and further research is needed to understand its potential benefits and risks.

1876-72-8

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1876-72-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1876-72-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,8,7 and 6 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1876-72:
(6*1)+(5*8)+(4*7)+(3*6)+(2*7)+(1*2)=108
108 % 10 = 8
So 1876-72-8 is a valid CAS Registry Number.

1876-72-8Downstream Products

1876-72-8Relevant academic research and scientific papers

A New ABCDE> Cycloaddition Strategy for the Approach to Yohimbe Alkaloids: Stereoselective Synthesis of (+/-)-3-epi-allo-Yohimbone

Gomez-Pardo, Domingo,d'Angelo, Jean

, p. 6637 - 6640 (2007/10/02)

Diels-Alder cycloaddition between lactam-sulfone 9 and diene 10 led to adducts 11 + 12 (30:1, respectively).Compound 11 has been converted in 4 steps into (+/-)-3-epi-allo-yohimbone 16.Key words: Diels-Alder cycloaddition, Yohimbe alkaloids, (+/-)-3-epi-a

GENERAL METHODS OF SYNTHESIS OF INDOLE ALKALOIDS - 14. SHORT ROUTES OF CONSTRUCTION OF YOHIMBOID AND AJMALICINOID ALKALOID SYSTEMS AND THEIR 13C NUCLEAR MAGNETIC RESONANCE SPECTRAL ANALYSIS.

Wenkert,Chang,Chawla,Cochran,Hagaman,King,orito

, p. 3645 - 3661 (2007/10/04)

Conceptually new schemes of synthesis of indole alkaloids are introduced. The yohimboid ring system is constructed by the sequential treatment of 1-tryptophyl-3-( beta -ketobutyl)pyridinium bromide with base and acid. Hydrogenation of the product yields d,l-pseudoyohimbone. The ajmalicinoid ring system is formed by the exposure of 1-tryptophyl-3-acetylpyridinium bromide to sodio dimethyl malonate and then to acid, followed by hydrogenation. Subsequent reduction and dehydration of the products lead to the racemates of the alkaloids tetrahydroalstonine and akuammigine as well as isomers of ajmalicine. Shifts of specific carbons are found to be of stereochemically diagnostic value.

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