187669-60-9

Basic information

• Product Name: 1-[4-(METHYLSULFONYL)PHENYL]PIPERAZINE
• Synonyms: 1-(4-Methylsulfonyl)phenyl]piperizine;Methyl 4-(piperazin-1-yl)phenyl sulphone;1-(4-mesylphenyl)piperazine;IDI1_001985;MixCom4_000241;Peakdale2_000513
• CAS NO: 187669-60-9
• Molecular Formula: C₁₁H₁₆N₂O₂S
• Molecular Weight: 240.33
• Mol File: 187669-60-9.mol
• Article Data: 9

Chemical Properties

• Melting Point: 136～138℃
• Boiling Point: 136～138℃
• Appearance: /
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 1-[4-(METHYLSULFONYL)PHENYL]PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[4-(METHYLSULFONYL)PHENYL]PIPERAZINE(187669-60-9)
• EPA Substance Registry System: 1-[4-(METHYLSULFONYL)PHENYL]PIPERAZINE(187669-60-9)

Safety Data

• Hazardous Substances Data: 187669-60-9(Hazardous Substances Data)

Usage

General Description

1-[4-(Methylsulfonyl)phenyl]piperazine is a chemical compound that belongs to the class of piperazine derivatives. It is often used as an intermediate in the synthesis of pharmaceuticals, specifically in the development of drugs with psychoactive or analgesic properties. The compound has a piperazine ring structure with a phenyl group substituted at the 1-position and a methylsulfonyl group substituted at the 4-position. It is known for its potential biological activity and has been studied for its role in modulating serotonin and dopamine receptors in the central nervous system. Additionally, it has been investigated for its potential as a therapeutic agent for the treatment of various neurological and psychiatric disorders.

Upstream product

• 166438-71-7 1-benzyl-4-[4-(methylsulfonyl)phenyl]piperazine 
• 110-85-0 piperazine 
• 455-15-2 1-(methylsufonyl)-4-fluorobenzene 
• 3466-32-8 4-bromoohenyl methyl sulfone 

Downstream Products

• 918884-07-8 4-{2-[4-(4-methanesulfonylphenyl)piperazin-1-yl]acetyl}piperidine-1-carboxylic acid tert-butyl ester 
• 946156-93-0 C₂₇H₃₅N₃O₄S 
• 1229627-95-5 rac-[4-(4-methanesulfonyl-phenyl)-piperazin-1-yl]-[5-methanesulfonyl-2-(2,2,2-trifluoro-1-methyl-ethoxy)phenyl]-methanone 
• 1396675-72-1 C₂HF₃O₂*C₂₃H₂₂ClN₅O₂S 
• 1095534-28-3 (1R,2R)-N-(1-cyanocyclopropyl)-2-{[4-[4-(methylsulfonyl)phenyl]piperazin-1-yl]carbonyl}cyclohexanecarboxamide 
• 1403499-38-6 (1R,2R)-N-(cyanomethyl)-2-[4-(4-methylsulfonylphenyl)piperazine-1-carbonyl]cyclohexanecarboxamide 

Relevant articles and documents

ADENOSINE RECEPTOR BINDING COMPOUNDS

The present invention relates to pharmaceutical compounds and compositions of Formula (I) and methods of treatment using the compounds and compositions, especially for the treatment and/or prevention of a proliferation disorder, such as cancer. Compounds of Formula (I) as further described herein are shown modulators of the adenosine A2A receptor and exhibit antiproliferative activity. Accordingly, these compounds are useful to treat proliferative disorders such as cancer, and other adenosine receptor-related conditions including an inflammatory disease, renal disease, diabetes, vascular disease, lung disease, or an autoimmune disease.

IMIDAZOLE DERIVATIVES

Described herein are compounds of formula (I), formula la or formula lb The compounds of formula I, formula la or formula lb act as DGATl inhibitors and can be useful in preventing, treating or acting as a remedial agent for hyperlipidemia, diabetes mellitus and obesity.

SAR of the arylpiperazine moiety of obeline somatostatin sst1 receptor antagonists

The SAR of over 50 derivatives of octahydrobenzo[g]quinoline (obeline)-type somatostatin sst1 receptor antagonist 1 is presented, focusing on the modification of its arylpiperazine moiety. Sst1 affinities in this series cover a range of five orders of magnitude with the best derivatives displaying subnanomolar sst1 affinities and >10,000-fold selectivities over the sst2 receptor subtype as well as promising pharmacokinetic properties.