187672-26-0Relevant academic research and scientific papers
Transformation of lignin model compounds to: N -substituted aromatics via Beckmann rearrangement
Wang, Yinling,Du, Yiman,He, Jianghua,Zhang, Yuetao
supporting information, p. 3318 - 3326 (2018/07/29)
Here we present the highly effective cleavage of C-C bonds in lignin model compounds for the production of N-substituted aromatics in up to 96% total yield, including benzonitriles and amides, via oxime formation followed by Beckmann rearrangement (BR). The amides could be further hydrolyzed to anilines (>92% yield) and carboxylic acids (>90% yield), respectively. In addition, the employment of a substrate with a γ-OH group will lead to the formation of C-2 monosubstituted oxazole. A one-pot process involving the BR reaction and hydrolysis has also been developed to directly afford an up to 96% total yield of benzonitriles, benzamides, and anilines. This strategy enabled us to successfully apply the BR reaction to the degradation of lignin model compounds to N-functionalized aromatic products under mild conditions.
Replacement of the Methylene of Dihydrochalcones with Oxygen: Synthesis and Biological Evaluation of 2-Phenoxyacetophenones
Ansari, Mahsa,Emami, Saeed,Khalilzadeh, Mohammad A.,Maghsoodlou, Malek T.,Foroumadi, Alireza,Faramarzi, Mohammad A.,Samadi, Nasrin,Ardestani, Sussan K.
, p. 591 - 597 (2012/11/07)
With the aim of finding new bioactive compounds, a series of phenoxyacetophenone derivatives 2 were designed and synthesized as oxygen analogs of dihydrochalcones. Also, phenoxyacetophenones were converted to (Z)-oxime derivatives 3 and their geometry wer
