187682-33-3

Upstream product

• 885703-19-5 (3S,4S)-4-N-phthalimido-1,5-hexadiene-3-ol 
• 1016976-13-8 3-benzyloxy-4-iodo-5-nitrobenzaldehyde 
• 1016976-14-9 methyl 3-amino-5-benzyloxy-4-iodobenzoate 
• 1016976-16-1 C₂₀H₂₇NO₃Si 
• 1016976-18-3 C₂₀H₂₉NO₅Si 
• 1016976-22-9 C₃₃H₅₁NO₄Si₂ 
• 1016976-36-5 C₁₇H₃₃NO₄Si 
• 1016976-12-7 C₁₇H₃₁NO₄Si 
• 1016976-23-0 C₃₂H₄₅IN₂O₆Si 
• 1016976-38-7 C₂₆H₃₁IN₂O₆ 
• 1016976-24-1 C₂₆H₂₉IN₂O₅ 
• 1016976-26-3 C₂₆H₂₈N₂O₅ 
• 1315454-73-9 C₂₈H₃₃IN₂O₈ 
• 15896-04-5 1,2-divinylethylene carbonate 

Downstream Products

• 1315455-49-2 C₂₇H₂₉N₃O₇ 
• 187682-52-6 methyl (1aS,8R,9S,9aS)-1,1a,2,8,9,9a-hexahydro-7-(benzyloxy)-8-{[(benzyloxycarbonyl)oxy]methyl}-1-(tert-butyloxycarbonyl)-8-formyl-9-hydroxy-3,9-epoxy-3H-azirino[2,3-c][1]benzazocin-5-carboxylate 
• 187682-49-1 methyl (1aS,8R,8aS,8bS)-1,1a,2,8,8a,8b-hexahydro-7-(benzyloxy)-8-{[(benzyloxycarbonyl)oxy]methyl}-1-(tert-butyloxycarbonyl)-8-formylazirino[2',3':3,4]pyrrolo[1,2-a]indole-5-carboxylate 3-oxide 
• 187682-48-0 methyl (1aS,8R,8aS,8bR)-1,1a,2,8,8a,8b-hexahydro-7-(benzyloxy)-8-{[(benzyloxycarbonyl)oxy]methyl}-1-(tert-butyloxycarbonyl)-8-formylazirino[2',3':3,4]pyrrolo[1,2-a]indole-5-carboxylate 
• 187682-44-6 methyl (1aS,8R,8aS,8bS)-1,1a,2,8,8a,8b-hexahydro-8-[(acetyloxy)methyl]-7-(benzyloxy)-1-(tert-butyloxycarbonyl)-8-formylazirino[2',3':3,4]pyrrolo[1,2-a]indole-5-carboxylate 3-oxide 
• 187682-45-7 methyl (1aS,8S,8bS)-1,1a,2,8,8a,8b-hexahydro-8-[(acetyloxy)methyl]-7-(benzyloxy)-1-(tert-butyloxycarbonyl)-8-formyl-8a-hydroxyazirino[2',3':3,4]pyrrolo[1,2-a]indole-5-carboxylate 
• 187682-43-5 methyl (1aS,8R,8aS,8bR)-1,1a,2,8,8a,8b-hexahydro-7-(benzyloxy)-8-[(acetyloxy)methyl]-1-(tert-butyloxycarbonyl)-8-formylazirino[2',3':3,4]pyrrolo[1,2-a]indole-5-carboxylate 
• 187682-39-9 methyl (1aS,8R,8aS,8bR)-1,1a,2,8,8a,8b-hexahydro-7-(benzyloxy)-1-(tert-butyloxycarbonyl)-8-formyl-8-(hydroxymethyl)azirino[2',3':3,4]pyrrolo[1,2-a]indole-5-carboxylate 
• 187682-40-2 C₂₆H₂₈N₂O₆ 

Relevant academic research and scientific papers

Development of a flexible strategy towards FR900482 and the mitomycins

FR900482 and the mitomycins are two intriguing classes of alkaloid natural products that have analogous biological mechanisms and obvious structural similarity. Both classes possess potent anticancer activity, a feature that has led to their investigation

Chiral aziridinyl radicals: An application to the synthesis of the core nucleus of FR-900482

An asymmetric route to the core nucleus of the antitumor agent FR-900482 utilizes the cyclization of an aziridinyl radical into a functionalized indole nucleus. The route employs a selective Polonovski reaction and the Hootele-Dmitrienko rearrangement to install two oxygen atoms.